%0 Case Reports
%T HIV-Negative Case of Talaromyces marneffei Pulmonary Infection with Liver Cirrhosis in China: A Case Report and Literature Review.
%A Liu Y
%A Guo H
%A Yuan W
%A Zou Y
%A Qian Z
%A Mei X
%A Ji L
%A Wang J
%A Zhang Y
%J Infect Drug Resist
%V 17
%N 0
%D 2024
%M 38596535
%F 4.177
%R 10.2147/IDR.S451880
%X <B>UNASSIGNED: </B>Talaromyces marneffei (TM) is the third most prevalent opportunistic infection in HIV-positive patients after tuberculosis and cryptococcosis. However, such infection of non-HIV individuals has rarely been reported.<BR><B>UNASSIGNED: </B>We describe a very rare case of a 52-year-old male who presented with a single space-occupying lesion on the right lung and was eventually diagnosed with pulmonary TM infection. The patient was HIV-negative and had liver cirrhosis with portal vein thrombosis. Lung tissue next-generation sequencing (NGS) revealed TM infection. We successfully treated the patient with voriconazole for 8 weeks and observed lesion absorption via subsequent CT. The patient consumed wild bamboo rats two months before admission. Mutations related to congenital immune deficiency were not detected by whole-exome sequencing.<BR><B>UNASSIGNED: </B>Early and timely diagnosis is critical for improving patient prognosis. NGS plays a vital role in the diagnosis of pulmonary TM infection in patients. To our knowledge, this is the first published case of pulmonary TM infection in an HIV-negative patient with liver cirrhosis.