PDF(Pubmed)
Abstract：
UNASSIGNED: This study assessed Nipah virus (NiV) encephalitis epidemiology, clinical outcomes, and risk variables to inform treatment and prevention.
UNASSIGNED: In a PubMed systematic search, 929 citations were found. After screening and eligibility, 22 studies were included. This study obtained age, gender, geographic regions, diagnostic methods, data collection methods, and bias risk. The case fatality rate (CFR) and NiV infection risk variables were evaluated by meta-analysis.
UNASSIGNED: Southeast Asia, especially Bangladesh and Malaysia, had the most NiV cases. The major diagnostic method was blood and cerebrospinal fluid IgM and IgG antibody tests, and males predominated. Proxy respondents and matched controls were utilized for risk factor analyses when patients could not answer. The pooled CFR for NiV encephalitis was 61.0%, indicating severity. Risk factors included pigs, nighttime bats near homes, tree climbing, and male gender.
UNASSIGNED: Southeast Asian public health is plagued by NiV encephalitis. The high CFR calls for better diagnosis, treatment, and prevention. NiV\'s multiple risk factors must be understood for targeted therapy. Future research should fill knowledge gaps and improve NiV infection prevention.
UNASSIGNED: In a PubMed systematic search, 929 citations were found. After screening and eligibility, 22 studies were included. This study obtained age, gender, geographic regions, diagnostic methods, data collection methods, and bias risk. The case fatality rate (CFR) and NiV infection risk variables were evaluated by meta-analysis.
UNASSIGNED: Southeast Asia, especially Bangladesh and Malaysia, had the most NiV cases. The major diagnostic method was blood and cerebrospinal fluid IgM and IgG antibody tests, and males predominated. Proxy respondents and matched controls were utilized for risk factor analyses when patients could not answer. The pooled CFR for NiV encephalitis was 61.0%, indicating severity. Risk factors included pigs, nighttime bats near homes, tree climbing, and male gender.
UNASSIGNED: Southeast Asian public health is plagued by NiV encephalitis. The high CFR calls for better diagnosis, treatment, and prevention. NiV\'s multiple risk factors must be understood for targeted therapy. Future research should fill knowledge gaps and improve NiV infection prevention.
摘要：
■这项研究评估了尼帕病毒（NiV）脑炎的流行病学，临床结果，和风险变量来告知治疗和预防。
■在PubMed系统搜索中，发现929条引文。经过筛选和资格，包括22项研究。这项研究获得了年龄，性别,地理区域,诊断方法,数据收集方法，和偏见风险。通过荟萃分析评估病死率（CFR）和NiV感染风险变量。
■东南亚，尤其是孟加拉国和马来西亚，NiV病例最多。主要诊断方法是血液和脑脊液IgM和IgG抗体测试，男性占主导地位。当患者无法回答时，使用代理受访者和匹配的对照进行风险因素分析。NiV脑炎的合并CFR为61.0%，指示严重性。危险因素包括猪，夜间蝙蝠靠近房屋，爬树,和男性性别。
■东南亚公共卫生受到NiV脑炎的困扰。高CFR要求更好的诊断，治疗,和预防。对于靶向治疗，必须了解NiV的多种危险因素。未来的研究应填补知识空白并改善NiV感染预防。
■在PubMed系统搜索中，发现929条引文。经过筛选和资格，包括22项研究。这项研究获得了年龄，性别,地理区域,诊断方法,数据收集方法，和偏见风险。通过荟萃分析评估病死率（CFR）和NiV感染风险变量。
■东南亚，尤其是孟加拉国和马来西亚，NiV病例最多。主要诊断方法是血液和脑脊液IgM和IgG抗体测试，男性占主导地位。当患者无法回答时，使用代理受访者和匹配的对照进行风险因素分析。NiV脑炎的合并CFR为61.0%，指示严重性。危险因素包括猪，夜间蝙蝠靠近房屋，爬树,和男性性别。
■东南亚公共卫生受到NiV脑炎的困扰。高CFR要求更好的诊断，治疗,和预防。对于靶向治疗，必须了解NiV的多种危险因素。未来的研究应填补知识空白并改善NiV感染预防。
