PDF(Pubmed)
Abstract：
Hepatoid adenocarcinoma (HAC) of the mediastinum is a rare extrahepatic tumour that pathologically and morphologically resembles hepatocellular carcinoma. Extrahepatic HACs primarily occur in the stomach, ovaries, lung, gallbladder, pancreas and uterus. Patients with mediastinal HAC tend to be male smokers over forty years of age. Clinical symptoms of HAC are non-specific and varied in nature; therefore, diagnosis can be challenging and often delayed. Diagnostic investigations encompass haematological, radiological and histological assessment. Surgical resection is reserved for early-stage patients; however, since diagnosis may be delayed, most patients present with metastatic disease, for which the treatment of choice is platinum-based chemotherapy.
摘要：
纵隔肝样腺癌（HAC）是一种罕见的肝外肿瘤，在病理和形态上类似于肝细胞癌。肝外HAC主要发生在胃中，卵巢,肺，胆囊,胰腺和子宫。纵隔HAC患者往往是40岁以上的男性吸烟者。HAC的临床症状是非特异性的，本质上是多种多样的；因此，诊断可能具有挑战性，并且经常延迟。诊断性调查包括血液学，放射学和组织学评估。手术切除保留给早期患者；然而，因为诊断可能会延迟，大多数患者都患有转移性疾病，选择的治疗方法是以铂类为基础的化疗。
