PDF(Pubmed)
Abstract：
Listeria monocytogenes is well recognized for both its broad resistance to stress conditions and its ability to transition from a soil bacterium to an intracellular pathogen of mammalian hosts. The bacterium\'s impressive ability to adapt to changing environments and conditions requires the rapid sensing of environmental cues and the coordinated response of gene products that enable bacterial growth and survival. Two-component signaling systems (TCSs) have been long recognized for their ability to detect environmental stimuli and transmit those signals into transcriptional responses; however, often the precise nature of the stimulus triggering TCS responses can be challenging to define. L. monocytogenes has up to 16 TCSs that have been recognized based on homology and included in this list are several whose functions remain poorly described. This review highlights the current understanding of the breadth and scope of L. monocytogenes TCS as relates to stress resistance and pathogenesis. Precise signals still often remain elusive, but the gene networks associated with TCSs are providing clues into possible functions.
摘要：
单核细胞增生李斯特菌因其对胁迫条件的广泛抗性及其从土壤细菌转变为哺乳动物宿主的细胞内病原体的能力而广为人知。细菌适应不断变化的环境和条件的令人印象深刻的能力需要快速感知环境线索和基因产物的协调反应，使细菌生长和生存。两组分信号传导系统(TCSs)因其检测环境刺激并将这些信号传递到转录反应中的能力而早已得到认可；然而，通常，触发TCS反应的刺激的确切性质可能难以定义。单核细胞增生李斯特菌具有多达16个TCS，这些TCS已根据同源性被识别，并且包括在该列表中的几种功能仍未得到充分描述。这篇综述强调了目前对单核细胞增生李斯特菌TCS的广度和范围的理解，这与应激抗性和发病机理有关。精确的信号仍然经常难以捉摸，但是与TCSs相关的基因网络为可能的功能提供了线索。
