Abstract：
UNASSIGNED: To evaluate the association between subclinical hypothyroidism with early menopause, premature menopause, and last menstrual bleeding before the natural age of menopause.
UNASSIGNED: This was a cross-sectional study conducted in 643 postmenopausal women aged 40-69 years. Groups were formed according to last menstrual episode: ≥45 [Natural age at menopause], 40-44 and [Early menopause], <40 [Premature menopause], and <45 [last menstrual episode before the natural age of menopause]. The Zulewski scale was applied to identify manifestations related to hypothyroidism and subclinical hypothyroidism, diagnosed with a serum TSH > 4.5 µIU/mL plus T4-free between 0.7 and 1.9 ng/dL.
UNASSIGNED: It was found that 24.4% had the last menstrual episode before the natural age of menopause, 18.6% had early menopause, and 5.7% had premature menopause. Subclinical hypothyroidism was diagnosed in 4.5% of patients. Among women with subclinical hypothyroidism, there was a higher frequency of early menopause, premature menopause, and last menstrual episode before the natural age of menopause, than in women without subclinical hypothyroidism (p < 0.05). Paresthesia (50%) and dry skin (40.7%) were the most reported hypothyroidism-related manifestations. Early menopause, premature menopause, and last menstrual episode before the natural age of menopause were associated with subclinical hypothyroidism, OR: 3.37 [95% CI: 1.40-8.10], OR: 4.31 [95% CI: 1.24-14.97], and OR: 3.57 [95% CI: 1.57-8.10], respectively.
UNASSIGNED: The last menstrual episode before the natural age of menopause, early menopause, and premature menopause were significantly associated with a higher chance of subclinical hypothyroidism.
UNASSIGNED: This was a cross-sectional study conducted in 643 postmenopausal women aged 40-69 years. Groups were formed according to last menstrual episode: ≥45 [Natural age at menopause], 40-44 and [Early menopause], <40 [Premature menopause], and <45 [last menstrual episode before the natural age of menopause]. The Zulewski scale was applied to identify manifestations related to hypothyroidism and subclinical hypothyroidism, diagnosed with a serum TSH > 4.5 µIU/mL plus T4-free between 0.7 and 1.9 ng/dL.
UNASSIGNED: It was found that 24.4% had the last menstrual episode before the natural age of menopause, 18.6% had early menopause, and 5.7% had premature menopause. Subclinical hypothyroidism was diagnosed in 4.5% of patients. Among women with subclinical hypothyroidism, there was a higher frequency of early menopause, premature menopause, and last menstrual episode before the natural age of menopause, than in women without subclinical hypothyroidism (p < 0.05). Paresthesia (50%) and dry skin (40.7%) were the most reported hypothyroidism-related manifestations. Early menopause, premature menopause, and last menstrual episode before the natural age of menopause were associated with subclinical hypothyroidism, OR: 3.37 [95% CI: 1.40-8.10], OR: 4.31 [95% CI: 1.24-14.97], and OR: 3.57 [95% CI: 1.57-8.10], respectively.
UNASSIGNED: The last menstrual episode before the natural age of menopause, early menopause, and premature menopause were significantly associated with a higher chance of subclinical hypothyroidism.
摘要：
■为了评估亚临床甲状腺功能减退症与早期绝经之间的关系，更年期过早,最后一次月经出血是在绝经期的自然年龄之前。
■这是一项针对643名40-69岁绝经后妇女的横断面研究。根据最后一次月经发作形成组：≥45[绝经时的自然年龄]，40-44和[早期更年期]，<40[过早绝经]，和<45[绝经期自然年龄之前的最后一次月经发作]。Zulewski量表用于识别与甲状腺功能减退症和亚临床甲状腺功能减退症相关的表现，诊断为血清TSH>4.5µIU/mL，无T4，介于0.7和1.9ng/dL之间。
■发现24.4%的人在绝经期的自然年龄之前有最后一次月经，18.6%的人有早期绝经,5.7%的人过早绝经。4.5%的患者诊断为亚临床甲状腺功能减退症。在患有亚临床甲状腺功能减退症的女性中，更年期早期的频率更高，更年期过早,在更年期的自然年龄之前的最后一次月经发作，无亚临床甲状腺功能减退症的女性（p<0.05）。感觉异常（50％）和皮肤干燥（40.7％）是最多的甲状腺功能减退相关表现。更年期提前,更年期过早,绝经自然年龄前的最后一次月经发作与亚临床甲状腺功能减退症有关，OR：3.37[95%CI：1.40-8.10]，OR：4.31[95%CI：1.24-14.97]，和OR：3.57[95%CI：1.57-8.10]，分别。
■绝经期自然年龄之前的最后一次月经发作，更年期提前,和过早绝经与亚临床甲状腺功能减退症的机会增加显著相关。
■这是一项针对643名40-69岁绝经后妇女的横断面研究。根据最后一次月经发作形成组：≥45[绝经时的自然年龄]，40-44和[早期更年期]，<40[过早绝经]，和<45[绝经期自然年龄之前的最后一次月经发作]。Zulewski量表用于识别与甲状腺功能减退症和亚临床甲状腺功能减退症相关的表现，诊断为血清TSH>4.5µIU/mL，无T4，介于0.7和1.9ng/dL之间。
■发现24.4%的人在绝经期的自然年龄之前有最后一次月经，18.6%的人有早期绝经,5.7%的人过早绝经。4.5%的患者诊断为亚临床甲状腺功能减退症。在患有亚临床甲状腺功能减退症的女性中，更年期早期的频率更高，更年期过早,在更年期的自然年龄之前的最后一次月经发作，无亚临床甲状腺功能减退症的女性（p<0.05）。感觉异常（50％）和皮肤干燥（40.7％）是最多的甲状腺功能减退相关表现。更年期提前,更年期过早,绝经自然年龄前的最后一次月经发作与亚临床甲状腺功能减退症有关，OR：3.37[95%CI：1.40-8.10]，OR：4.31[95%CI：1.24-14.97]，和OR：3.57[95%CI：1.57-8.10]，分别。
■绝经期自然年龄之前的最后一次月经发作，更年期提前,和过早绝经与亚临床甲状腺功能减退症的机会增加显著相关。
