PDF(Pubmed)
Abstract：
BACKGROUND: Non-invasive techniques such as central intermittent theta burst stimulation (iTBS) and repetitive peripheral magnetic stimulation (rPMS) have shown promise in improving motor function for patients with stroke. However, the combined efficacy of rPMS and central iTBS has not been extensively studied. This randomized controlled trial aimed to investigate the synergistic effects of rPMS and central iTBS in patients with stroke.
METHODS: In this study, 28 stroke patients were randomly allocated to receive either 1200 pulses of real or sham rPMS on the radial nerve of the affected limb, followed by 1200 pulses of central iTBS on the ipsilesional hemisphere. The patients received the intervention for 10 sessions over two weeks. The primary outcome measures were the Fugl-Meyer Assessment-Upper Extremity (FMA-UE) and the Action Research Arm Test (ARAT). Secondary outcomes for activities and participation included the Functional Independence Measure-Selfcare (FIM-Selfcare) and the Stroke Impact Scale (SIS). The outcome measures were assessed before and after the intervention.
RESULTS: Both groups showed significant improvement in FMA-UE and FIM-Selfcare after the intervention (p < 0.05). Only the rPMS + iTBS group had significant improvement in ARAT-Grasp and SIS-Strength and activity of daily living (p < 0.05). However, the change scores in all outcome measures did not differ between two groups.
CONCLUSIONS: Overall, the study\'s findings suggest that rPMS may have a synergistic effect on central iTBS to improve grasp function and participation. In conclusion, these findings highlight the potential of rPMS as an adjuvant therapy for central iTBS in stroke rehabilitation. Further large-scale studies are needed to fully explore the synergistic effects of rPMS on central iTBS.
BACKGROUND: This trial was registered under ClinicalTrials.gov ID No.NCT04265365, retrospectively registered, on February 11, 2020.
METHODS: In this study, 28 stroke patients were randomly allocated to receive either 1200 pulses of real or sham rPMS on the radial nerve of the affected limb, followed by 1200 pulses of central iTBS on the ipsilesional hemisphere. The patients received the intervention for 10 sessions over two weeks. The primary outcome measures were the Fugl-Meyer Assessment-Upper Extremity (FMA-UE) and the Action Research Arm Test (ARAT). Secondary outcomes for activities and participation included the Functional Independence Measure-Selfcare (FIM-Selfcare) and the Stroke Impact Scale (SIS). The outcome measures were assessed before and after the intervention.
RESULTS: Both groups showed significant improvement in FMA-UE and FIM-Selfcare after the intervention (p < 0.05). Only the rPMS + iTBS group had significant improvement in ARAT-Grasp and SIS-Strength and activity of daily living (p < 0.05). However, the change scores in all outcome measures did not differ between two groups.
CONCLUSIONS: Overall, the study\'s findings suggest that rPMS may have a synergistic effect on central iTBS to improve grasp function and participation. In conclusion, these findings highlight the potential of rPMS as an adjuvant therapy for central iTBS in stroke rehabilitation. Further large-scale studies are needed to fully explore the synergistic effects of rPMS on central iTBS.
BACKGROUND: This trial was registered under ClinicalTrials.gov ID No.NCT04265365, retrospectively registered, on February 11, 2020.
摘要：
背景：非侵入性技术，如中枢间歇性θ脉冲刺激（iTBS）和重复外周磁刺激（rPMS），已显示出改善中风患者运动功能的前景。然而,rPMS和中枢iTBS的联合疗效尚未得到广泛研究.这项随机对照试验旨在研究rPMS和中枢iTBS在卒中患者中的协同作用。
方法：在本研究中，28例中风患者被随机分配接受1200脉冲的真实或假rPMS在患肢的radial神经上，随后在同侧半球出现1200脉冲的中央iTBS。患者在两周内接受了10次干预。主要结果指标是Fugl-Meyer评估上肢（FMA-UE）和动作研究手臂测试（ARAT）。活动和参与的次要结果包括功能独立性措施-自我护理（FIM-Selfcare）和卒中影响量表（SIS）。在干预前后评估结局指标。
结果：两组干预后FMA-UE和FIM-Selfcare均有明显改善（p<0.05）。只有rPMS+iTBS组在ARAT-Grasp和SIS-强度和日常生活活动能力方面有显著改善(p<0.05)。然而,两组间所有结局指标的变化评分均无差异.
结论：总体而言，研究结果表明，rPMS可能对中枢iTBS具有协同作用，以改善抓握功能和参与。总之,这些发现凸显了rPMS在卒中康复中作为中枢iTBS辅助治疗的潜力.需要进一步的大规模研究来充分探索rPMS对中枢iTBS的协同作用。
背景：该试验在ClinicalTrials.govIDNo.NCT04265365，回顾性注册，2020年2月11日。
方法：在本研究中，28例中风患者被随机分配接受1200脉冲的真实或假rPMS在患肢的radial神经上，随后在同侧半球出现1200脉冲的中央iTBS。患者在两周内接受了10次干预。主要结果指标是Fugl-Meyer评估上肢（FMA-UE）和动作研究手臂测试（ARAT）。活动和参与的次要结果包括功能独立性措施-自我护理（FIM-Selfcare）和卒中影响量表（SIS）。在干预前后评估结局指标。
结果：两组干预后FMA-UE和FIM-Selfcare均有明显改善（p<0.05）。只有rPMS+iTBS组在ARAT-Grasp和SIS-强度和日常生活活动能力方面有显著改善(p<0.05)。然而,两组间所有结局指标的变化评分均无差异.
结论：总体而言，研究结果表明，rPMS可能对中枢iTBS具有协同作用，以改善抓握功能和参与。总之,这些发现凸显了rPMS在卒中康复中作为中枢iTBS辅助治疗的潜力.需要进一步的大规模研究来充分探索rPMS对中枢iTBS的协同作用。
背景：该试验在ClinicalTrials.govIDNo.NCT04265365，回顾性注册，2020年2月11日。
