METHODS: 47 patients were reviewed. Complications were distinguished in early and late whether they occurred before or after 30 days from surgery. Overall survival (OS), disease-free survival (DFS) and local recurrence-free survival (LRFS) were calculated by the Kaplan-Meier product-limit method from surgery until relapse or death.
RESULTS: 27 patients presented to observation after a first intralesional approach in a non-specialized center. Chordoma was the most represented histotype. Vertebrectomies were: 23 one-level, 10 two-level, 12 three-level and 2 four-level. Reconstructions were always carried out with screws and rods. The main postoperative complication was blood loss, while hardware failure was the main long-term complication. The 5-year LRFS was 75.5%, the 5-year DFS was 54.3%, and 5-year OS was 63.6%.
CONCLUSIONS: The surgical margin obtained during the index surgery was statistically associated with Local Recurrence, DFS and OS, underlining the importance of treating patients in reference centers.
方法:对47例患者进行回顾性分析。无论并发症发生在手术前30天还是手术后30天,都在早期和晚期进行区分。总生存期(OS),通过Kaplan-Meier乘积限制法计算从手术到复发或死亡的无病生存期(DFS)和无局部复发生存期(LRFS).
结果:27例患者在非专业中心进行首次病灶内治疗后接受观察。脊索瘤是最具代表性的组织型。椎体切除术为:23个一级,10两层,12个三级和2个四级。重建总是用螺钉和杆进行。术后主要并发症为失血,而硬件故障是主要的长期并发症。5年期LRFS为75.5%,5年DFS为54.3%,5年OS为63.6%。
结论:索引手术期间获得的手术切缘与局部复发有统计学关联,DFS和操作系统,强调在参考中心治疗患者的重要性。