Abstract：
Amyloid fibril formation is a general property of proteins and peptides. It is a physicochemical phenomenon similar to crystallization, in which amyloid precursor proteins exceeding solubility precipitate through the breakdown of supersaturation. Using the ultrasonication-forced amyloid fibril inducer HANABI, we have discovered that serum albumin acts as an inhibitor in dialysis-related amyloidosis. Exploring the factors that induce or inhibit amyloid fibril formation using HANABI can lead to the development of early diagnosis and prevention methods for amyloidosis.
摘要：
淀粉样原纤维的形成是蛋白质和肽的一般性质。它是一种类似于结晶的物理化学现象，其中超过溶解度的淀粉样蛋白前体蛋白通过过饱和的分解而沉淀。使用超声强制淀粉样蛋白原纤维诱导剂HANABI，我们发现血清白蛋白在透析相关淀粉样变性中具有抑制剂的作用.使用HANABI探索诱导或抑制淀粉样蛋白原纤维形成的因素可以导致淀粉样变性的早期诊断和预防方法的发展。
