{Reference Type}: English Abstract
{Title}: [New Development in Amyloidosis Research Based on Supersaturation: Biological Factors to Induce/Inhibit the Amyloid Fibril Formation].
{Author}: Yamaguchi K;Nakajima K;Goto Y;
{Journal}: Brain Nerve
{Volume}: 76
{Issue}: 4
{Year}: 2024 Apr
暂无{DOI}: 10.11477/mf.1416202616
{Abstract}: Amyloid fibril formation is a general property of proteins and peptides. It is a physicochemical phenomenon similar to crystallization, in which amyloid precursor proteins exceeding solubility precipitate through the breakdown of supersaturation. Using the ultrasonication-forced amyloid fibril inducer HANABI, we have discovered that serum albumin acts as an inhibitor in dialysis-related amyloidosis. Exploring the factors that induce or inhibit amyloid fibril formation using HANABI can lead to the development of early diagnosis and prevention methods for amyloidosis.