Abstract：
OBJECTIVE: In this study, it was aimed to examine the antibacterial activity of the essential oil components (EOCs), carvacrol (CAR), cinnamaldehyde (CIN), thymol (TH), alpha pinene (α-PN), eucalyptol (EU), limonene (LIM), and the antibiotics, linezolid (LZD), vancomycin (VAN), gentamicin (GEN), ciprofloxacin (CIP), clindamycin (CLN), and penicillin (PEN) against 50 multidrug resistant Corynebacterium striatum strains, and the synergistic interactions of CAR and CIN with the antibiotics against 10 randomly selected Coryne. striatum strains to explore synergistic interactions to determine if their combined use could enhance antibiotic activity and potentially reduce resistance.
RESULTS: The activity of the EOCs and the antibiotics against Coryne. striatum strains isolated from clinical specimens, was examined by broth microdilution method. The synergistic interactions of the EOCs with the antibiotics against 10 randomly selected Coryne. striatum strains were determined by checkerboard method. EOCs, CIN, and CAR and antibiotics, LZD, VAN, GEN, CIP, and CLN were detected to have antibacterial activity against Coryne. striatum strains alone and either synergistic interactions were observed in combinations of the antibiotics with EOCs.
CONCLUSIONS: All Coryne. striatum strains were determined to be susceptible to VAN and LZD and resistant to GEN, PEN, CIP, and CLN. Synergistic interactions were observed in all combinations of antibiotics tested with CAR and CIN.
RESULTS: The activity of the EOCs and the antibiotics against Coryne. striatum strains isolated from clinical specimens, was examined by broth microdilution method. The synergistic interactions of the EOCs with the antibiotics against 10 randomly selected Coryne. striatum strains were determined by checkerboard method. EOCs, CIN, and CAR and antibiotics, LZD, VAN, GEN, CIP, and CLN were detected to have antibacterial activity against Coryne. striatum strains alone and either synergistic interactions were observed in combinations of the antibiotics with EOCs.
CONCLUSIONS: All Coryne. striatum strains were determined to be susceptible to VAN and LZD and resistant to GEN, PEN, CIP, and CLN. Synergistic interactions were observed in all combinations of antibiotics tested with CAR and CIN.
摘要：
目的：在本研究中，它的目的是检查精油成分（EOCs）的抗菌活性，香芹酚(CAR),肉桂醛（CIN），百里酚（TH），α-pine烯（α-PN），桉树脑(欧盟)，柠檬烯（LIM）和抗生素，利奈唑胺(LZD),万古霉素(VAN),庆大霉素（GEN），环丙沙星(CIP),克林霉素（CLN）和青霉素（PEN）对50株耐多药纹状体棒状杆菌，以及CAR和CIN与抗生素对10种随机选择的纹状体梭菌菌株的协同相互作用，以探索协同相互作用，以确定它们的联合使用是否可以增强抗生素活性并可能降低耐药性。
结果：EOCs和抗生素对从临床标本中分离的纹状体梭菌菌株的活性，通过肉汤微量稀释法检查。通过棋盘方法测定EOCs与抗生素对10种随机选择的纹状体梭菌菌株的协同相互作用。EOCs,CIN和CAR和抗生素，LZD,货车,GEN,检测到CIP和CLN单独对纹状体梭菌菌株具有抗菌活性,并且在抗生素与EOCs的组合中观察到任一协同相互作用。
结论：确定所有纹状体C.菌株对VAN敏感，LZD和GEN抗性，PEN,CIP和CLN。在用CAR和CIN测试的所有抗生素组合中观察到协同相互作用。
结果：EOCs和抗生素对从临床标本中分离的纹状体梭菌菌株的活性，通过肉汤微量稀释法检查。通过棋盘方法测定EOCs与抗生素对10种随机选择的纹状体梭菌菌株的协同相互作用。EOCs,CIN和CAR和抗生素，LZD,货车,GEN,检测到CIP和CLN单独对纹状体梭菌菌株具有抗菌活性,并且在抗生素与EOCs的组合中观察到任一协同相互作用。
结论：确定所有纹状体C.菌株对VAN敏感，LZD和GEN抗性，PEN,CIP和CLN。在用CAR和CIN测试的所有抗生素组合中观察到协同相互作用。
