PDF(Pubmed)
Abstract：
UNASSIGNED: Perioperative intravenous (IV) infusions of lidocaine and esketamine reduce postoperative pain, but there are few studies on the quality of recovery and patients\' emotional states postoperatively. We aimed to explore the effects of perioperative IV lidocaine and esketamine on the quality of recovery and emotional state after thyroidectomy.
UNASSIGNED: In this randomised trial, 137 patients undergoing thyroidectomy were randomly assigned to three groups: a lidocaine group (Group L), an esketamine group (Group E) and a normal saline placebo group (Group C). The primary outcome was the Quality of Recovery 40 (QoR-40) on postoperative days (PODs) 1 and 2. The secondary outcomes included Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores on days 1 and 2 after surgery, pain scores, opioid consumption and incidence of postoperative nausea and vomiting (PONV). Statistical analysis was performed using the one-way analysis of variance (ANOVA), the Kruskal-Wallis and Chi-square tests.
UNASSIGNED: The global QoR-40 scores in groups L and E on POD 1 and POD 2 were significantly higher than in group C (P < 0.001). The SAS and SDS scores on POD 1 and POD 2 in groups L and E were significantly lower than in group C (P < 0.05). There were statistically significant differences in Numerical Rating Scale (NRS) scores among the three groups at 1 h, 2 h, 6 h and 12 h (P < 0.05).
UNASSIGNED: Perioperative IV lidocaine and esketamine improve the quality of postoperative recovery and the emotional state of patients undergoing thyroidectomy.
UNASSIGNED: In this randomised trial, 137 patients undergoing thyroidectomy were randomly assigned to three groups: a lidocaine group (Group L), an esketamine group (Group E) and a normal saline placebo group (Group C). The primary outcome was the Quality of Recovery 40 (QoR-40) on postoperative days (PODs) 1 and 2. The secondary outcomes included Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores on days 1 and 2 after surgery, pain scores, opioid consumption and incidence of postoperative nausea and vomiting (PONV). Statistical analysis was performed using the one-way analysis of variance (ANOVA), the Kruskal-Wallis and Chi-square tests.
UNASSIGNED: The global QoR-40 scores in groups L and E on POD 1 and POD 2 were significantly higher than in group C (P < 0.001). The SAS and SDS scores on POD 1 and POD 2 in groups L and E were significantly lower than in group C (P < 0.05). There were statistically significant differences in Numerical Rating Scale (NRS) scores among the three groups at 1 h, 2 h, 6 h and 12 h (P < 0.05).
UNASSIGNED: Perioperative IV lidocaine and esketamine improve the quality of postoperative recovery and the emotional state of patients undergoing thyroidectomy.
摘要：
■围手术期静脉（IV）输注利多卡因和艾氯胺酮可减少术后疼痛，但很少有关于术后恢复质量和患者情绪状态的研究。我们旨在探讨围手术期静脉注射利多卡因和艾氯胺酮对甲状腺切除术后恢复质量和情绪状态的影响。
■在这项随机试验中，137例接受甲状腺切除术的患者被随机分为三组：利多卡因组（L组），艾氯胺酮组（E组）和生理盐水安慰剂组（C组）。主要结果是术后第1天和第2天（PODs）的恢复质量40（QoR-40）。次要结局包括术后第1天和第2天的焦虑自评量表（SAS）和抑郁自评量表（SDS）评分，疼痛评分,阿片类药物的消耗和术后恶心和呕吐（PONV）的发生率。使用单向方差分析(ANOVA)进行统计分析，Kruskal-Wallis和卡方检验.
■在POD1和POD2上，L和E组的总体QoR-40得分明显高于C组（P<0.001）。L组和E组POD1和POD2的SAS和SDS评分均显著低于C组(P<0.05)。1h时三组间数值评定量表(NRS)评分差异有统计学意义,2h,6h和12h(P<0.05)。
■围手术期静脉注射利多卡因和艾氯胺酮可改善甲状腺切除术患者的术后恢复质量和情绪状态。
■在这项随机试验中，137例接受甲状腺切除术的患者被随机分为三组：利多卡因组（L组），艾氯胺酮组（E组）和生理盐水安慰剂组（C组）。主要结果是术后第1天和第2天（PODs）的恢复质量40（QoR-40）。次要结局包括术后第1天和第2天的焦虑自评量表（SAS）和抑郁自评量表（SDS）评分，疼痛评分,阿片类药物的消耗和术后恶心和呕吐（PONV）的发生率。使用单向方差分析(ANOVA)进行统计分析，Kruskal-Wallis和卡方检验.
■在POD1和POD2上，L和E组的总体QoR-40得分明显高于C组（P<0.001）。L组和E组POD1和POD2的SAS和SDS评分均显著低于C组(P<0.05)。1h时三组间数值评定量表(NRS)评分差异有统计学意义,2h,6h和12h(P<0.05)。
■围手术期静脉注射利多卡因和艾氯胺酮可改善甲状腺切除术患者的术后恢复质量和情绪状态。
