Abstract：
UNASSIGNED: Protein microarray is a promising immunomic approach for identifying biomarkers. Based on our previous study that reviewed parasite antigens and recent parasitic omics research, this article expands to include information on vector-borne parasitic diseases (VBPDs), namely, malaria, schistosomiasis, leishmaniasis, babesiosis, trypanosomiasis, lymphatic filariasis, and onchocerciasis.
UNASSIGNED: We revisit and systematically summarize antigen markers of vector-borne parasites identified by the immunomic approach and discuss the latest advances in identifying antigens for the rational development of diagnostics and vaccines. The applications and challenges of this approach for VBPD control are also discussed.
UNASSIGNED: The immunomic approach has enabled the identification and/or validation of antigen markers for vaccine development, diagnosis, disease surveillance, and treatment. However, this approach presents several challenges, including limited sample size, variability in antigen expression, false-positive results, complexity of omics data, validation and reproducibility, and heterogeneity of diseases. In addition, antigen involvement in host immune evasion and antigen sensitivity/specificity are major issues in its application. Despite these limitations, this approach remains promising for controlling VBPD. Advances in technology and data analysis methods should continue to improve candidate antigen identification, as well as the use of a multiantigen approach in diagnostic and vaccine development for VBPD control.
UNASSIGNED: We revisit and systematically summarize antigen markers of vector-borne parasites identified by the immunomic approach and discuss the latest advances in identifying antigens for the rational development of diagnostics and vaccines. The applications and challenges of this approach for VBPD control are also discussed.
UNASSIGNED: The immunomic approach has enabled the identification and/or validation of antigen markers for vaccine development, diagnosis, disease surveillance, and treatment. However, this approach presents several challenges, including limited sample size, variability in antigen expression, false-positive results, complexity of omics data, validation and reproducibility, and heterogeneity of diseases. In addition, antigen involvement in host immune evasion and antigen sensitivity/specificity are major issues in its application. Despite these limitations, this approach remains promising for controlling VBPD. Advances in technology and data analysis methods should continue to improve candidate antigen identification, as well as the use of a multiantigen approach in diagnostic and vaccine development for VBPD control.
摘要：
■蛋白质微阵列是用于鉴定生物标志物的有前途的免疫组学方法。基于我们先前的研究，回顾了寄生虫抗原和最近的寄生虫组学研究，这篇文章扩展到包括媒介传播寄生虫病(VBPDs)的信息，即,疟疾,血吸虫病,利什曼病,babesiosis,锥虫病,淋巴丝虫病，还有盘尾丝虫病.
■我们回顾并系统地总结了通过免疫组学方法鉴定的载体寄生虫的抗原标记，并讨论了鉴定抗原的最新进展，以合理开发诊断和疫苗。还讨论了这种方法在VBPD控制中的应用和挑战。
■免疫组学方法使得能够鉴定和/或验证用于疫苗开发的抗原标记，诊断,疾病监测,和治疗。然而,这种方法提出了几个挑战，包括有限的样本量，抗原表达的变异性，假阳性结果,组学数据的复杂性，验证和再现性，和疾病的异质性。此外,抗原参与宿主免疫逃避和抗原敏感性/特异性是其应用的主要问题。尽管有这些限制,这种方法对于控制VBPD仍然很有希望。技术和数据分析方法的进步应继续提高候选抗原的鉴定，以及在VBPD控制的诊断和疫苗开发中使用多抗原方法。
■我们回顾并系统地总结了通过免疫组学方法鉴定的载体寄生虫的抗原标记，并讨论了鉴定抗原的最新进展，以合理开发诊断和疫苗。还讨论了这种方法在VBPD控制中的应用和挑战。
■免疫组学方法使得能够鉴定和/或验证用于疫苗开发的抗原标记，诊断,疾病监测,和治疗。然而,这种方法提出了几个挑战，包括有限的样本量，抗原表达的变异性，假阳性结果,组学数据的复杂性，验证和再现性，和疾病的异质性。此外,抗原参与宿主免疫逃避和抗原敏感性/特异性是其应用的主要问题。尽管有这些限制,这种方法对于控制VBPD仍然很有希望。技术和数据分析方法的进步应继续提高候选抗原的鉴定，以及在VBPD控制的诊断和疫苗开发中使用多抗原方法。
