Abstract：
BACKGROUND: Biliary tract cancer (BTC) is an invasive adenocarcinoma affecting the hepatobiliary system, but high recurrence rates highlight the need for more effective adjuvant approaches. The modified Glasgow prognostic score (mGPS) has been explored as an independent prognostic indicator in patients with BTC. However, consensus on its prognostic value is lacking. This meta-analysis aimed to comprehensively assess the association between mGPS and diverse clinical outcomes in BTC by systematically analyzing relevant studies.
METHODS: A systematic search approach was used to look for eligible papers published until June 2023 in PubMed, Web of Science, and Embase, with a focus on overall survival (OS) and disease-free/recurrence-free survival (DFS/RFS). The prognostic potential of mGPS was assessed using hazard ratios (HRs) with corresponding 95% CIs.
RESULTS: A total of 15 papers comprising 2447 patients were included in this meta-analysis. The results demonstrated that, in patients with BTC, the high mGPS was associated with poorer OS (HR=1.49, 95% CI=1.35-1.65, P<0.001) and DFS/RFS (HR=3.23, 95%CI=1.98-5.26, P=0.193).
CONCLUSIONS: According to this meta-analysis, our study found that high mGPS was associated with poorer OS and DFS/RFS in patients with BTC.
METHODS: A systematic search approach was used to look for eligible papers published until June 2023 in PubMed, Web of Science, and Embase, with a focus on overall survival (OS) and disease-free/recurrence-free survival (DFS/RFS). The prognostic potential of mGPS was assessed using hazard ratios (HRs) with corresponding 95% CIs.
RESULTS: A total of 15 papers comprising 2447 patients were included in this meta-analysis. The results demonstrated that, in patients with BTC, the high mGPS was associated with poorer OS (HR=1.49, 95% CI=1.35-1.65, P<0.001) and DFS/RFS (HR=3.23, 95%CI=1.98-5.26, P=0.193).
CONCLUSIONS: According to this meta-analysis, our study found that high mGPS was associated with poorer OS and DFS/RFS in patients with BTC.
摘要：
背景：胆道癌（BTC）是一种影响肝胆系统的浸润性腺癌，但高复发率突出表明需要更有效的辅助治疗方法.已探索改良的格拉斯哥预后评分（mGPS）作为BTC患者的独立预后指标。然而,对其预后价值缺乏共识。这项荟萃分析旨在通过系统分析相关研究，全面评估mGPS与BTC不同临床结果之间的关联。
方法：使用系统搜索方法来寻找截止到2023年6月在PubMed上发表的合格论文，WebofScience,和Embase,重点关注总生存期（OS）和无病/无复发生存期（DFS/RFS）。使用风险比（HRs）和相应的95%CIs评估mGPS的预后潜力。
结果：本荟萃分析共纳入15篇论文，包括2447名患者。结果表明,在BTC患者中，高mGPS与较差的OS(HR=1.49,95%CI=1.35-1.65,P<0.001)和DFS/RFS(HR=3.23,95CI=1.98-5.26,P=0.193)相关。
结论：根据本荟萃分析，我们的研究发现,在BTC患者中,高mGPS与较差的OS和DFS/RFS相关.
方法：使用系统搜索方法来寻找截止到2023年6月在PubMed上发表的合格论文，WebofScience,和Embase,重点关注总生存期（OS）和无病/无复发生存期（DFS/RFS）。使用风险比（HRs）和相应的95%CIs评估mGPS的预后潜力。
结果：本荟萃分析共纳入15篇论文，包括2447名患者。结果表明,在BTC患者中，高mGPS与较差的OS(HR=1.49,95%CI=1.35-1.65,P<0.001)和DFS/RFS(HR=3.23,95CI=1.98-5.26,P=0.193)相关。
结论：根据本荟萃分析，我们的研究发现,在BTC患者中,高mGPS与较差的OS和DFS/RFS相关.
