Abstract：
BACKGROUND: Ischemic heart diseases (IHD), characterized by metabolic dysregulation, contributes majorly to the global morbidity and mortality. Glucose, lipid and amino acid metabolism are critical energy production for cardiomyocytes, and disturbances of these metabolism lead to the cardiac injury. Traditional Chinese medicine (TCM), widely used for treating IHD, have been demonstrated to effectively and safely regulate the cardiac metabolism reprogramming.
OBJECTIVE: This study discussed and analyzed the disturbed cardiac metabolism induced by IHD and development of formulas, extracts, single herb, bioactive compounds of TCM ameliorating IHD injury via metabolism regulation, with the aim of providing a basis for the development of clinical application of therapeutic strategies for TCM in IHD.
METHODS: With \"ischemic heart disease\", \"myocardial infarction\", \"myocardial ischemia\", \"metabolomics\", \"Chinese medicine\", \"herb\", \"extracts\" \"medicinal plants\", \"glucose\", \"lipid metabolism\", \"amino acid\" as the main keywords, PubMed, Web of Science, and other online search engines were used for literature retrieval.
RESULTS: IHD exhibits a close association with metabolism disorders, including but not limited to glycolysis, the TCA cycle, oxidative phosphorylation, branched-chain amino acids, fatty acid β-oxidation, ketone body metabolism, sphingolipid and glycerol-phospholipid metabolism. The therapeutic potential of TCM lies in its ability to regulate these disturbed cardiac metabolisms. Additionally, the active ingredients of TCM have depicted wonderful effects in cardiac metabolism reprogramming in IHD.
CONCLUSIONS: Drawing from the principles of TCM, we have pinpointed specific herbal remedies for the treatment of IHD, and leveraged advanced metabolomics technologies to uncover the effect of these TCMs on metabolomics alteration. In the future, further clinical experimental studies should be included to explore whether more TCM medicines can play a therapeutic role in IHD by reversing cardiac metabolism disorders; multi-omics would be conducted to explore more pathways and genes targeting such metabolism reprogramming by TCMs, and to seek more TCM therapies for IHD.
OBJECTIVE: This study discussed and analyzed the disturbed cardiac metabolism induced by IHD and development of formulas, extracts, single herb, bioactive compounds of TCM ameliorating IHD injury via metabolism regulation, with the aim of providing a basis for the development of clinical application of therapeutic strategies for TCM in IHD.
METHODS: With \"ischemic heart disease\", \"myocardial infarction\", \"myocardial ischemia\", \"metabolomics\", \"Chinese medicine\", \"herb\", \"extracts\" \"medicinal plants\", \"glucose\", \"lipid metabolism\", \"amino acid\" as the main keywords, PubMed, Web of Science, and other online search engines were used for literature retrieval.
RESULTS: IHD exhibits a close association with metabolism disorders, including but not limited to glycolysis, the TCA cycle, oxidative phosphorylation, branched-chain amino acids, fatty acid β-oxidation, ketone body metabolism, sphingolipid and glycerol-phospholipid metabolism. The therapeutic potential of TCM lies in its ability to regulate these disturbed cardiac metabolisms. Additionally, the active ingredients of TCM have depicted wonderful effects in cardiac metabolism reprogramming in IHD.
CONCLUSIONS: Drawing from the principles of TCM, we have pinpointed specific herbal remedies for the treatment of IHD, and leveraged advanced metabolomics technologies to uncover the effect of these TCMs on metabolomics alteration. In the future, further clinical experimental studies should be included to explore whether more TCM medicines can play a therapeutic role in IHD by reversing cardiac metabolism disorders; multi-omics would be conducted to explore more pathways and genes targeting such metabolism reprogramming by TCMs, and to seek more TCM therapies for IHD.
摘要：
背景：缺血性心脏病（IHD），以代谢失调为特征，对全球发病率和死亡率的贡献很大。葡萄糖,脂质和氨基酸代谢是心肌细胞产生能量的关键，这些代谢紊乱导致心脏损伤。中药(TCM),广泛用于治疗IHD，已被证明可以有效和安全地调节心脏代谢重编程。
目的：本研究讨论并分析了IHD引起的心脏代谢紊乱以及配方的开发，摘录,单一草药，中药活性化合物通过代谢调节改善IHD损伤，目的是为IHD中医治疗策略的临床应用提供依据。
方法：使用“缺血性心脏病”，“心肌梗塞”，“心肌缺血”，“代谢组学”，\"中药\",\"herb\",\"提取物\"\"药用植物\",“葡萄糖”，“脂质代谢”，以“氨基酸”为主要关键词，PubMed,WebofScience,和其他在线搜索引擎被用于文献检索。
结果：IHD与代谢紊乱密切相关，包括但不限于糖酵解，TCA循环,氧化磷酸化，支链氨基酸，脂肪酸β-氧化，酮体代谢,鞘脂和甘油磷脂代谢。中医的治疗潜力在于其调节这些受干扰的心脏代谢的能力。此外,中药的有效成分在IHD的心脏代谢重编程中具有出色的作用。
结论：从中医原理出发，我们已经确定了治疗IHD的特定草药，并利用先进的代谢组学技术来揭示这些TCM对代谢组学改变的影响。在未来,应包括进一步的临床实验研究，以探索更多的中药是否可以通过逆转心脏代谢紊乱在IHD中发挥治疗作用；将进行多组学研究，以探索更多针对TCM重新编程的代谢途径和基因，并为IHD寻求更多的中医疗法。
目的：本研究讨论并分析了IHD引起的心脏代谢紊乱以及配方的开发，摘录,单一草药，中药活性化合物通过代谢调节改善IHD损伤，目的是为IHD中医治疗策略的临床应用提供依据。
方法：使用“缺血性心脏病”，“心肌梗塞”，“心肌缺血”，“代谢组学”，\"中药\",\"herb\",\"提取物\"\"药用植物\",“葡萄糖”，“脂质代谢”，以“氨基酸”为主要关键词，PubMed,WebofScience,和其他在线搜索引擎被用于文献检索。
结果：IHD与代谢紊乱密切相关，包括但不限于糖酵解，TCA循环,氧化磷酸化，支链氨基酸，脂肪酸β-氧化，酮体代谢,鞘脂和甘油磷脂代谢。中医的治疗潜力在于其调节这些受干扰的心脏代谢的能力。此外,中药的有效成分在IHD的心脏代谢重编程中具有出色的作用。
结论：从中医原理出发，我们已经确定了治疗IHD的特定草药，并利用先进的代谢组学技术来揭示这些TCM对代谢组学改变的影响。在未来,应包括进一步的临床实验研究，以探索更多的中药是否可以通过逆转心脏代谢紊乱在IHD中发挥治疗作用；将进行多组学研究，以探索更多针对TCM重新编程的代谢途径和基因，并为IHD寻求更多的中医疗法。
