Abstract：
Objective: The aim of this paper is to compare the refractive correction effects of rigid gas permeable contact lenses (RGPCL) and spectacle correction in children with aphakia after congenital cataract surgery. Methods: This was a prospective non-randomized controlled trial. Children with aphakic eyes after congenital cataract surgery, who underwent vision correction in the Strabismus and Pediatric Ophthalmology Clinic of Beijing Tongren Hospital affiliated with Capital Medical University from April 2012 to November 2019, were continuously collected. Those who voluntarily chose to wear RGPCL for refractive correction were included in the experimental group. Patients with monocular disease were in trial group 1, and patients with binocular disease were in trial group 2. Patients who chose to wear frame glasses for refractive correction were included in the control group. Patients with monocular disease were in control group 1, and patients with binocular disease were in control group 2. Regional origin, medical history, and family information were collected at the first diagnosis. During the follow-up, adverse reactions occurring during the process of wearing glasses were recorded. The Teller acuity card was used for visual examination to obtain the best-corrected visual acuity and convert it into the logarithm of the minimum resolution angle. The degree of nystagmus was determined according to the amplitude and frequency of nystagmus. Treatment cost, treatment compliance, and the reasons for adopting or not adopting RGPCL were analyzed through a questionnaire completed by the parents of children with RGPCL. Results: A total of 203 children (344 eyes) who underwent congenital cataract surgery were included, including 124 males (210 eyes) and 79 females (134 eyes). The age range was 3 to 36 months. There were 28 cases in the experimental group, including 19 cases in trial group 1 and 9 cases in trial group 2. There were 175 cases in the control group, including 43 cases in control group 1 and 132 cases in control group 2. Except for 6 months of age, the visual acuity of the experimental group was better than that of the control group, and the differences were statistically significant (P<0.05). The visual acuity of children in trial group 1 was better than that of children in control group 1 at the same age. Among them, at 12 months of age [1.54 (1.27, 1.97), 1.84 (0.97, 2.12)], 18 months of age [1.27 (0.97, 1.84), 1.84 (0.97, 2.12)], 24 months of age [1.54 (1.27, 1.84), 1.84 (0.97, 2.12)], and 30 months old [0.97 (0.66, 1.27), 1.54 (0.66, 2.12)], the difference was statistically significant (P<0.001). The visual acuity of children in trial group 2 was better than that in control group 2 at the same age. Among them, at 18 months old [1.27 (0.97, 1.54), 1.27 (0.66, 2.12)], 24 months old [0.97 (0.66, 1.27), 1.27 (0.66, 2.12)], and 30 months old [1.27 (0.66, 2.12)], the difference was statistically significant (P<0.05). The remission rate of nystagmus in the experimental group was 8/9 (8 cases), the remission rate of nystagmus in the control group was 34.40% (32 cases), and the exacerbation rate was 29.03% (27 cases). The average annual cost of the experimental group was 25 125 yuan, and that of the control group was 2 511 yuan. Conclusions: RGPCL is a well-tolerated, safe, and effective treatment for infants and young children. The visual acuity and degree of nystagmus were significantly improved in children who wore RGPCL for aphakia refractive correction after congenital cataract surgery compared with spectacle correction.
目的： 比较先天性白内障术后无晶状体眼患儿使用硬性透气性角膜接触镜（RGPCL）和框架眼镜进行屈光矫正的效果和影响因素。 方法： 前瞻性非随机对照试验。连续收集2012年4月至2019年11月于首都医科大学附属北京同仁医院斜视与小儿眼科门诊进行视力矫正的先天性白内障术后无晶状体眼患儿，将自主选择配戴RGPCL进行屈光矫正者纳入试验组，其中单眼发病者为试验1组，双眼发病者为试验2组；将术后自主选择配戴框架眼镜进行屈光矫正者纳入对照组，其中单眼发病者为对照1组，双眼发病者为对照2组。首诊时采集患儿地区来源、病史和家庭情况等信息。随访时记录戴镜过程中出现的不良反应；采用Teller视敏度卡进行视力检查获取最佳矫正视力并转换为最小分辨角的对数；根据眼球震颤振幅和频率确定眼球震颤的程度；分析治疗费用、遮盖治疗依从性；对患儿家长进行采用或不采用RGPCL原因的问卷调查。 结果： 最终纳入先天性白内障术后患儿203例（344只眼），其中男性124例（210只眼），女性79例（134只眼）；年龄为3~36个月。试验组28例，其中试验1组19例，双眼试验2组9例；对照组175例，其中对照1组43例，对照2组132例。除6月龄外，其余各月龄的试验组患儿视力均优于对照组患儿，差异均具有统计学意义（P<0.05）。试验1组患儿各月龄视力均优于对照1组同月龄患儿视力，其中12月龄［1.54（1.27，1.97）、1.84（0.97，2.12）］、18月龄［1.27（0.97，1.84）、1.84（0.97，2.12）］、24月龄［1.27（0.66，1.54）、1.54（0.66，2.12）］及30月龄［0.97（0.66，1.27）、1.54（0.66，2.12）］视力的差异有统计学意义（P<0.001）；试验2组患儿各月龄视力均优于对照2组同月龄患儿视力，其中18月龄［1.27（0.97，1.54）、1.27（0.66，2.12）］、24月龄［0.97（0.66，1.27）、1.27（0.66，2.12）］及30月龄［0.66（0.66，1.27）、1.27（0.66，2.12）］视力差异有统计学意义（P<0.05）。试验组眼球震颤缓解率为8/9（8例），对照组眼球震颤缓解率为34.40%（32例），加重率为29.03%（27例）。试验组年均费用为25 125元，对照组年均费用为2 511元。 结论： 对于婴幼儿患者，RGPCL是一种可耐受程度较高且安全有效的治疗方法。相较于框架眼镜，佩戴RGPCL进行先天性白内障术后无晶状体眼屈光矫正的患儿视力及眼球震颤程度有显著改善。.
目的： 比较先天性白内障术后无晶状体眼患儿使用硬性透气性角膜接触镜（RGPCL）和框架眼镜进行屈光矫正的效果和影响因素。 方法： 前瞻性非随机对照试验。连续收集2012年4月至2019年11月于首都医科大学附属北京同仁医院斜视与小儿眼科门诊进行视力矫正的先天性白内障术后无晶状体眼患儿，将自主选择配戴RGPCL进行屈光矫正者纳入试验组，其中单眼发病者为试验1组，双眼发病者为试验2组；将术后自主选择配戴框架眼镜进行屈光矫正者纳入对照组，其中单眼发病者为对照1组，双眼发病者为对照2组。首诊时采集患儿地区来源、病史和家庭情况等信息。随访时记录戴镜过程中出现的不良反应；采用Teller视敏度卡进行视力检查获取最佳矫正视力并转换为最小分辨角的对数；根据眼球震颤振幅和频率确定眼球震颤的程度；分析治疗费用、遮盖治疗依从性；对患儿家长进行采用或不采用RGPCL原因的问卷调查。 结果： 最终纳入先天性白内障术后患儿203例（344只眼），其中男性124例（210只眼），女性79例（134只眼）；年龄为3~36个月。试验组28例，其中试验1组19例，双眼试验2组9例；对照组175例，其中对照1组43例，对照2组132例。除6月龄外，其余各月龄的试验组患儿视力均优于对照组患儿，差异均具有统计学意义（P<0.05）。试验1组患儿各月龄视力均优于对照1组同月龄患儿视力，其中12月龄［1.54（1.27，1.97）、1.84（0.97，2.12）］、18月龄［1.27（0.97，1.84）、1.84（0.97，2.12）］、24月龄［1.27（0.66，1.54）、1.54（0.66，2.12）］及30月龄［0.97（0.66，1.27）、1.54（0.66，2.12）］视力的差异有统计学意义（P<0.001）；试验2组患儿各月龄视力均优于对照2组同月龄患儿视力，其中18月龄［1.27（0.97，1.54）、1.27（0.66，2.12）］、24月龄［0.97（0.66，1.27）、1.27（0.66，2.12）］及30月龄［0.66（0.66，1.27）、1.27（0.66，2.12）］视力差异有统计学意义（P<0.05）。试验组眼球震颤缓解率为8/9（8例），对照组眼球震颤缓解率为34.40%（32例），加重率为29.03%（27例）。试验组年均费用为25 125元，对照组年均费用为2 511元。 结论： 对于婴幼儿患者，RGPCL是一种可耐受程度较高且安全有效的治疗方法。相较于框架眼镜，佩戴RGPCL进行先天性白内障术后无晶状体眼屈光矫正的患儿视力及眼球震颤程度有显著改善。.
摘要：
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