Abstract：
Complement-stimulated neutrophils are able to adhere to the endothelium and damage endothelial cells both in vitro and in vivo. These blood cells participate in the early stages, growth and complications of atherosclerotic plaques. Recent findings, based on mendelian randomization analysis, support the concept that high neutrophil counts are a causal risk factor for ischemic heart disease and myocardial infarction . Clopidogrel decreases leukocyte count and inflammatory markers in patients with acute coronary syndromes; this off-target effect, which is independent of the antiplatelet action, may help explaining secondary prevention data showing a superiority of clopidogrel over aspirin in reducing new cardiovascular events.
摘要：
补体刺激的嗜中性粒细胞能够粘附于内皮并在体外和体内损伤内皮细胞。这些血细胞参与早期阶段，动脉粥样硬化斑块的生长和并发症。最近的发现,基于孟德尔随机化分析，支持高中性粒细胞计数是缺血性心脏病和心肌梗死的因果危险因素这一观点.氯吡格雷降低急性冠脉综合征患者的白细胞计数和炎症标志物；这种脱靶效应，这与抗血小板作用无关，可能有助于解释二级预防数据显示氯吡格雷在减少新的心血管事件方面优于阿司匹林.
