Abstract：
Retinal oximetry could provide insights into the pathophysiology of optic nerve disease, including optic disc drusen (ODD). Vessel selection for oximetry analysis is based on morphological characteristics of arterioles and venules and supported by an overlay of estimated blood oxygen saturations. The purpose of this cross-sectional study was to determine the validity of this vessel selection procedure by comparing it with vessel selection supported by video fluorescein angiography (FA). The study included 36 eyes of 36 patients with ODD who underwent retinal oximetry (Oxymap retinal oximeter T1) followed by FA (Heidelberg Spectralis). Two trained graders selected vessel segments in a pre-defined measurement area around the optic disc. One of these graders additionally performed the vessel segment selection with the support of FA images. When performed by the same grader, FA-supported and non-FA-supported vessel selection did not lead to significant differences in total vessel segment length, estimated oxygen saturations or vessel diameters (all p > 0.05). Inter-grader differences were found for arterial and venous segment lengths and arterial saturation (p < 0.05). A similar tendency was found for the arteriovenous saturation difference (p = 0.10). In conclusion, identifying vessel segments for retinal oximetry analysis based on vessel morphology and supported by a color-coded saturation overlay appears to be a valid method without the need for invasive angiography. A numerically small inter-grader variation may influence oximetry results. Further studies of retinal oximetry in ODD are warranted.
摘要：
视网膜血氧定量可以提供对视神经疾病的病理生理学的见解，包括视盘玻璃疣（ODD）。血氧饱和度分析的血管选择基于小动脉和小静脉的形态特征，并得到估计的血氧饱和度的叠加支持。这项横断面研究的目的是通过将其与视频荧光素血管造影（FA）支持的血管选择进行比较，以确定该血管选择程序的有效性。该研究包括36例ODD患者的36只眼，这些患者接受了视网膜血氧饱和度（Oxymap视网膜血氧计T1），然后接受了FA（海德堡光谱）。两名受过训练的分级者在视盘周围的预定义测量区域中选择血管段。这些分级者中的一个还在FA图像的支持下执行血管段选择。当同一个分级者执行时，FA支持和非FA支持的血管选择并未导致总血管段长度的显着差异，估计氧饱和度或血管直径(所有p>0.05)。在动脉和静脉段长度和动脉饱和度方面发现了年级之间的差异（p<0.05）。动静脉饱和度差异也有类似的趋势（p=0.10）。总之,根据血管形态和颜色编码的饱和度叠加图,识别用于视网膜血氧饱和度分析的血管段似乎是一种有效的方法,不需要侵入性血管造影.数值较小的年级间变化可能会影响血氧测定结果。有必要对ODD中的视网膜血氧测定进行进一步研究。
