RESULTS: In the Bladder Cancer Epidemiology, Wellness, and Lifestyle Study (Be-Well Study), a prospective cohort of 1472 incident NMIBC patients, dietary ITC exposure is assessed by self-reported CV intake and measured in plasma ITC-albumin adducts. Using Cox proportional hazards regression models, stratified by single nucleotide polymorphisms (SNPs) in nine key ITC-metabolizing/functioning genes, it is calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for recurrence and progression. The rs15561 in N-acetyltransferase 1 (NAT1) is alter the association between CV intake and progression risk. Multiple SNPs in nuclear factor E2-related factor 2 (NRF2) and nuclear factor kappa B (NFκB) are modify the associations between plasma ITC-albumin adduct level and progression risk (pint < 0.05). No significant association is observed with recurrence risk. Overall, >80% study participants are present with at least one protective genotype per gene, showing an average 65% reduction in progression risk with high dietary ITC exposure.
CONCLUSIONS: Despite that genetic variations in ITC-metabolizing/functioning genes may modify the effect of dietary ITCs on NMIBC prognosis, dietary recommendation of CV consumption may help improve NMIBC survivorship.
结果:在膀胱癌流行病学中,健康,和生活方式研究(Be-WellStudy),1472例NMIBC患者的前瞻性队列,通过自我报告的CV摄入量评估膳食ITC暴露,并在血浆ITC-白蛋白加合物中测量。使用Cox比例风险回归模型,通过9个关键ITC代谢/功能基因的单核苷酸多态性(SNP)分层,计算复发和进展的风险比(HR)和95%置信区间(CIs).N-乙酰转移酶1(NAT1)中的rs15561改变了CV摄入与进展风险之间的关联。核因子E2相关因子2(NRF2)和核因子κB(NFκB)中的多个SNP修饰了血浆ITC-白蛋白加合物水平与进展风险之间的关联(pint<0.05)。没有观察到与复发风险的显著关联。总的来说,>80%的研究参与者每个基因至少有一个保护性基因型,显示高膳食ITC暴露的进展风险平均降低65%。
结论:尽管ITC代谢/功能基因的遗传变异可能会改变膳食ITC对NMIBC预后的影响,饮食建议食用CV可能有助于提高NMIBC的生存率。