PDF(Pubmed)
Abstract：
OBJECTIVE: The purpose of this article is to systematically review the association between dry eye and sleep quality.
METHODS: PubMed, EMBASE, Cochrane, Web of Science, and grey literature databases were searched for observational studies published before April 2023. Meta-analysis was performed using STAT15 software.
RESULTS: A total of 21 studies with 419,218 participants were included. The results showed that the dry eye subjects had a worse sleep quality than the healthy population, with poorer subjective sleep quality, longer sleep latency, and a higher risk of unhealthy sleep duration such as insufficient sleep or excessive sleep. The Pittsburgh Sleep Quality Index (PSQI) scores of the dry eye subjects were significantly higher than those of the control subjects (WMD = 1.78, 95%CI: 1.06, 2.50, P < 0.001). The dry eye subjects scored higher than the control subjects in sleep quality, sleep latency, and sleep disturbance in PSQI; there was no difference between the dry eye individuals and control subjects in sleep duration, sleep efficiency, daytime dysfunction, and sleep medication scores. The risk of sleep disorders in the dry eye subjects was significantly higher than that in the non-dry eye subjects (RR = 2.20, 95%CI: 1.78, 2.72, P < 0.001); the risk of insufficient sleep in the dry eye subjects was higher than that in the control subjects (RR = 3.76, 95%CI: 3.15, 4.48, P < 0.001), and the prevalence of excessive sleepiness in dry eye subjects was higher than that in the control subjects (RR = 5.53, 95%CI: 3.83, 7.18, P < 0.001). The ESS scores of the dry eye subjects were significantly higher than those of the control subjects (WMD = 3.02, 95%CI: 2.43, 3.60, P < 0.01).
CONCLUSIONS: Our meta-analysis suggests that individuals with dry eye have a worse sleep quality than the healthy population, with poorer subjective sleep quality, longer sleep latency, and higher risk of unhealthy sleep duration such as insufficient sleep or excessive sleepiness.
METHODS: PubMed, EMBASE, Cochrane, Web of Science, and grey literature databases were searched for observational studies published before April 2023. Meta-analysis was performed using STAT15 software.
RESULTS: A total of 21 studies with 419,218 participants were included. The results showed that the dry eye subjects had a worse sleep quality than the healthy population, with poorer subjective sleep quality, longer sleep latency, and a higher risk of unhealthy sleep duration such as insufficient sleep or excessive sleep. The Pittsburgh Sleep Quality Index (PSQI) scores of the dry eye subjects were significantly higher than those of the control subjects (WMD = 1.78, 95%CI: 1.06, 2.50, P < 0.001). The dry eye subjects scored higher than the control subjects in sleep quality, sleep latency, and sleep disturbance in PSQI; there was no difference between the dry eye individuals and control subjects in sleep duration, sleep efficiency, daytime dysfunction, and sleep medication scores. The risk of sleep disorders in the dry eye subjects was significantly higher than that in the non-dry eye subjects (RR = 2.20, 95%CI: 1.78, 2.72, P < 0.001); the risk of insufficient sleep in the dry eye subjects was higher than that in the control subjects (RR = 3.76, 95%CI: 3.15, 4.48, P < 0.001), and the prevalence of excessive sleepiness in dry eye subjects was higher than that in the control subjects (RR = 5.53, 95%CI: 3.83, 7.18, P < 0.001). The ESS scores of the dry eye subjects were significantly higher than those of the control subjects (WMD = 3.02, 95%CI: 2.43, 3.60, P < 0.01).
CONCLUSIONS: Our meta-analysis suggests that individuals with dry eye have a worse sleep quality than the healthy population, with poorer subjective sleep quality, longer sleep latency, and higher risk of unhealthy sleep duration such as insufficient sleep or excessive sleepiness.
摘要：
目的：本文的目的是系统地回顾干眼与睡眠质量之间的关系。
方法：PubMed，EMBASE,科克伦,WebofScience,和灰色文献数据库搜索2023年4月之前发表的观察性研究。采用STAT15软件进行Meta分析。
结果：共纳入21项研究，419,218名参与者。结果显示,干眼症受试者的睡眠质量比健康人群差,主观睡眠质量较差，更长的睡眠潜伏期，和不健康的睡眠持续时间，如睡眠不足或过度睡眠的风险较高。干眼症受试者的匹兹堡睡眠质量指数(PSQI)得分明显高于对照组(WMD=1.78,95CI:1.06,2.50,P<0.001)。干眼症受试者的睡眠质量得分高于对照组，睡眠潜伏期，和PSQI中的睡眠障碍；干眼症个体与对照组之间的睡眠持续时间没有差异，睡眠效率，日间功能障碍,和睡眠药物评分。干眼受试者睡眠障碍风险明显高于非干眼受试者(RR=2.20,95CI:1.78,2.72,P<0.001);干眼受试者睡眠不足风险高于对照组(RR=3.76,95CI:3.15,4.48,P<0.001),干眼受试者过度嗜睡的患病率高于对照组(RR=5.53,95CI:3.83,7.18,P<0.001)。干眼症患者的ESS评分明显高于对照组(WMD=3.02,95CI:2.43,3.60,P<0.01)。
结论：我们的荟萃分析表明，干眼症患者的睡眠质量比健康人群差，主观睡眠质量较差，更长的睡眠潜伏期，以及不健康睡眠持续时间的高风险，如睡眠不足或过度嗜睡。
方法：PubMed，EMBASE,科克伦,WebofScience,和灰色文献数据库搜索2023年4月之前发表的观察性研究。采用STAT15软件进行Meta分析。
结果：共纳入21项研究，419,218名参与者。结果显示,干眼症受试者的睡眠质量比健康人群差,主观睡眠质量较差，更长的睡眠潜伏期，和不健康的睡眠持续时间，如睡眠不足或过度睡眠的风险较高。干眼症受试者的匹兹堡睡眠质量指数(PSQI)得分明显高于对照组(WMD=1.78,95CI:1.06,2.50,P<0.001)。干眼症受试者的睡眠质量得分高于对照组，睡眠潜伏期，和PSQI中的睡眠障碍；干眼症个体与对照组之间的睡眠持续时间没有差异，睡眠效率，日间功能障碍,和睡眠药物评分。干眼受试者睡眠障碍风险明显高于非干眼受试者(RR=2.20,95CI:1.78,2.72,P<0.001);干眼受试者睡眠不足风险高于对照组(RR=3.76,95CI:3.15,4.48,P<0.001),干眼受试者过度嗜睡的患病率高于对照组(RR=5.53,95CI:3.83,7.18,P<0.001)。干眼症患者的ESS评分明显高于对照组(WMD=3.02,95CI:2.43,3.60,P<0.01)。
结论：我们的荟萃分析表明，干眼症患者的睡眠质量比健康人群差，主观睡眠质量较差，更长的睡眠潜伏期，以及不健康睡眠持续时间的高风险，如睡眠不足或过度嗜睡。
