碱基编辑的人类类器官中膀胱发生的遗传学揭示了多囊肾疾病的治疗策略。
关键词: ADPKD autosomal dominant polycystic kidney disease distal tubule drug discovery gentamicin nephron precision medicine protein translation proximal tubule renal ribosome
Mesh : Humans Mice Animals Codon, Nonsense / metabolism TRPP Cation Channels / genetics metabolism Polycystic Kidney Diseases / genetics therapy metabolism Kidney / metabolism Organoids / metabolism Cysts / genetics metabolism Glycosides / metabolism
来 源:
DOI:10.1016/j.stem.2024.03.005
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