Abstract：
The pathophysiology of several illnesses, including cancer and autoimmune diseasesdepends on human regulatory T cells (Tregs), and abnormalities in these cells may function as triggers for these conditions. Cancer and autoimmune, and gynecological diseases are associated with the differentiation of the proinflammatory T cell subset TH17 and its balance with the production of Treg. Recently, long non-coding RNAs (lncRNAs) have become important regulatory molecules in a wide range of illnesses. During epigenetic regulation, they can control the expression of important genes at several levels by affecting transcription, post-transcriptional actions, translation, and protein modification. They might connect with different molecules, such as proteins, DNA and RNA, and their structural composition is intricate. Because lncRNAs regulatebiological processes, including cell division, death, and growth, they are linked to severaldiseases. A notable instance of this is the lncRNA NEAT1, which has been the subject of several investigations to ascertain its function in immune cell development. In the context of immune cell development, several additional lncRNAs have been connected to Treg cell differentiation. In this work, we summarize current findings about the diverse functions of lncRNAs in Treg cell differentiation and control of the Th17/Treg homeostasis in autoimmune disorders, cancers, as well as several gynecological diseases where Tregs are key players.
摘要：
几种疾病的病理生理学，包括癌症和自身免疫性疾病依赖于人类调节性T细胞（Tregs），这些细胞中的异常可能是这些疾病的触发因素。癌症和自身免疫，和妇科疾病与促炎T细胞亚群TH17的分化及其与Treg的产生的平衡有关。最近,长链非编码RNA（lncRNAs）已成为多种疾病的重要调控分子。在表观遗传调控过程中，它们可以通过影响转录在几个水平上控制重要基因的表达，转录后的作用，翻译,和蛋白质修饰。它们可能与不同的分子连接，如蛋白质，DNA和RNA,它们的结构组成错综复杂。因为lncRNAs调节生物过程，包括细胞分裂,死亡,和增长，它们与几种疾病有关。一个值得注意的例子是lncRNANEAT1，它已经成为几项研究的主题，以确定其在免疫细胞发育中的功能。在免疫细胞发育的背景下，一些额外的lncRNAs已经与Treg细胞分化有关。在这项工作中,我们总结了lncRNAs在Treg细胞分化和自身免疫性疾病中Th17/Treg稳态控制中的不同功能的最新发现，癌症,以及Tregs是关键参与者的几种妇科疾病。
