PDF(Pubmed)
Abstract：
BACKGROUND: Inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) of the liver is rare. It was previously believed that Epstein-Barr virus (EBV) positivity was a necessary criterion for pathological diagnosis. However, we found that there were also cases of EBV negativity. Therefore, clinicians and pathologists are reminded that EBV positivity is not a necessary condition for diagnosis.
METHODS: A 70-year-old female underwent computed tomography (CT) examination for upper abdominal discomfort, which revealed the presence of a liver tumor. Follow-up revealed that the tumor had progressively increased in size.
METHODS: The final diagnosis was an IPT-like follicular cell sarcoma, based on CT, MRI, HE staining, and immunohistochemical staining.
METHODS: The patient underwent a laparoscopic left hemihepatectomy.
RESULTS: The patient has not undergone any special treatment, such as radiotherapy and chemotherapy, and has been followed up for over 3 years without experiencing any recurrence.
CONCLUSIONS: IPT-like FDCS is a rare tumor that lacks definitive criteria, and its diagnosis mainly relies on pathological findings. Previously, it was believed that being EBV-positive was an important condition for diagnosis. Primary IPT-like FDCS in the liver is even rarer, and the patient in this case tested negative for EBV. It may be necessary for pathologists to consider the role of EBV in the diagnosis of IPT-like FDCS.
METHODS: A 70-year-old female underwent computed tomography (CT) examination for upper abdominal discomfort, which revealed the presence of a liver tumor. Follow-up revealed that the tumor had progressively increased in size.
METHODS: The final diagnosis was an IPT-like follicular cell sarcoma, based on CT, MRI, HE staining, and immunohistochemical staining.
METHODS: The patient underwent a laparoscopic left hemihepatectomy.
RESULTS: The patient has not undergone any special treatment, such as radiotherapy and chemotherapy, and has been followed up for over 3 years without experiencing any recurrence.
CONCLUSIONS: IPT-like FDCS is a rare tumor that lacks definitive criteria, and its diagnosis mainly relies on pathological findings. Previously, it was believed that being EBV-positive was an important condition for diagnosis. Primary IPT-like FDCS in the liver is even rarer, and the patient in this case tested negative for EBV. It may be necessary for pathologists to consider the role of EBV in the diagnosis of IPT-like FDCS.
摘要：
背景：肝脏的炎性假瘤样滤泡树突状细胞肉瘤（IPT样FDCS）很少见。以前认为EB病毒（EBV）阳性是病理诊断的必要标准。然而,我们发现也有EBV阴性的情况。因此,提醒临床医生和病理学家，EBV阳性不是诊断的必要条件。
方法：一名70岁的女性因上腹不适接受了计算机断层扫描（CT）检查，显示肝脏肿瘤的存在.随访显示肿瘤的大小逐渐增加。
方法：最终诊断为IPT样滤泡细胞肉瘤，基于CT,MRI,HE染色,和免疫组织化学染色。
方法：患者接受了腹腔镜左半肝切除术。
结果：患者未接受任何特殊治疗，如放疗和化疗，随访3年以上，无任何复发。
结论：IPT样FDCS是一种罕见的肿瘤，缺乏明确的标准，其诊断主要依靠病理结果。以前,人们认为EBV阳性是诊断的重要条件.肝脏中的原发性IPT样FDCS甚至更罕见，在这种情况下，患者的EBV检测呈阴性。病理学家可能需要考虑EBV在IPT样FDCS诊断中的作用。
方法：一名70岁的女性因上腹不适接受了计算机断层扫描（CT）检查，显示肝脏肿瘤的存在.随访显示肿瘤的大小逐渐增加。
方法：最终诊断为IPT样滤泡细胞肉瘤，基于CT,MRI,HE染色,和免疫组织化学染色。
方法：患者接受了腹腔镜左半肝切除术。
结果：患者未接受任何特殊治疗，如放疗和化疗，随访3年以上，无任何复发。
结论：IPT样FDCS是一种罕见的肿瘤，缺乏明确的标准，其诊断主要依靠病理结果。以前,人们认为EBV阳性是诊断的重要条件.肝脏中的原发性IPT样FDCS甚至更罕见，在这种情况下，患者的EBV检测呈阴性。病理学家可能需要考虑EBV在IPT样FDCS诊断中的作用。
