%0 Case Reports
%T EBER-negative inflammatory pseudotumor-like follicular dendritic cell sarcoma of liver: A case report.
%A Zhang Q
%A Gao J
%J Medicine (Baltimore)
%V 103
%N 14
%D 2024 Apr 5
%M 38579046
%F 1.817
%R 10.1097/MD.0000000000037651
%X <B>BACKGROUND: </B>Inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) of the liver is rare. It was previously believed that Epstein-Barr virus (EBV) positivity was a necessary criterion for pathological diagnosis. However, we found that there were also cases of EBV negativity. Therefore, clinicians and pathologists are reminded that EBV positivity is not a necessary condition for diagnosis.<BR><B>METHODS: </B>A 70-year-old female underwent computed tomography (CT) examination for upper abdominal discomfort, which revealed the presence of a liver tumor. Follow-up revealed that the tumor had progressively increased in size.<BR><B>METHODS: </B>The final diagnosis was an IPT-like follicular cell sarcoma, based on CT, MRI, HE staining, and immunohistochemical staining.<BR><B>METHODS: </B>The patient underwent a laparoscopic left hemihepatectomy.<BR><B>RESULTS: </B>The patient has not undergone any special treatment, such as radiotherapy and chemotherapy, and has been followed up for over 3 years without experiencing any recurrence.<BR><B>CONCLUSIONS: </B>IPT-like FDCS is a rare tumor that lacks definitive criteria, and its diagnosis mainly relies on pathological findings. Previously, it was believed that being EBV-positive was an important condition for diagnosis. Primary IPT-like FDCS in the liver is even rarer, and the patient in this case tested negative for EBV. It may be necessary for pathologists to consider the role of EBV in the diagnosis of IPT-like FDCS.