Abstract：
Ocular drug delivery is constrained by anatomical and physiological barriers, necessitating innovative solutions for effective therapy. Natural polymers like hyaluronic acid, chitosan, and gelatin, alongside synthetic counterparts such as PLGA and PEG, have gained prominence for their biocompatibility and controlled release profiles. Recent strides in polymer conjugation strategies have enabled targeted delivery through ligand integration, facilitating tissue specificity and cellular uptake. This versatility accommodates combined drug delivery, addressing diverse anterior (e.g., glaucoma, dry eye) and posterior segment (e.g., macular degeneration, diabetic retinopathy) afflictions. The review encompasses an in-depth exploration of each natural and synthetic polymer, detailing their individual advantages and disadvantages for ocular drug delivery. By transcending ocular barriers and refining therapeutic precision, these innovations promise to reshape the management of anterior and posterior segment eye diseases.
摘要：
眼部药物输送受到解剖和生理障碍的限制，需要创新的解决方案来进行有效的治疗。像透明质酸这样的天然聚合物，壳聚糖,和明胶，与PLGA和PEG等合成对应物一起，因其生物相容性和控释特性而获得突出地位。聚合物缀合策略的最新进展使得能够通过配体整合进行靶向递送,促进组织特异性和细胞摄取。这种多功能性适应组合药物输送，解决不同的前部(例如，青光眼,干眼)和后段(例如，黄斑变性,糖尿病视网膜病变）的痛苦。该综述包括对每种天然和合成聚合物的深入探索，详细说明他们各自的优点和缺点的眼部给药。通过超越眼屏障和提高治疗精度，这些创新有望重塑眼前段和后段眼病的管理。
