PDF(Pubmed)
Abstract：
UNASSIGNED: Since 1964, there has been a scarcity of reported cases of primary ameloblastoma (AM) or ameloblastic carcinoma (AMCa) of the skull. The clinical presentation and distinctive features of this uncommon condition at specific anatomical sites remain unclear. We report a case of malignant transformation of a primary AM of the skull situated in the frontal-temporal-parietal region and highlight its similarities to other cases reported in the literature.
UNASSIGNED: A 53-year-old female patient presented with a 20-day history of headaches and bilateral lower limb weakness for 10 days. Physical examination revealed slow and unsteady gait. An occupying lesion was observed in the right frontal-temporal-parietal region of the skull on the Cranial imaging. A right cranial bone tumor margin expansion resection was performed. The patient\'s motor functions recovered normally after surgery. Postoperative imaging examinations showed10 tumor resection. Follow-up imaging examinations showed tumor recurrence. The patient underwent resection of the recurrent tumor. Postoperative pathological analysis revealed malignant transformation of the AM.Follow-up imaging examinations showed tumor recurrence again. The patient was admitted for stereotactic radiotherapy. Follow-up imaging examinations demonstrated no evidence of tumor recurrence and subsequent chest CT revealed no signs of metastasis.
UNASSIGNED: Primary AM or AMCa of the skull is increasingly being described in the literature, but detailed reports on the malignant transformation of primary AM of the skull are lacking. The pathogenesis of this condition remains unclear. Aggressive treatment and close follow-up may be crucial for preventing disease recurrence and malignant transformation.
UNASSIGNED: A 53-year-old female patient presented with a 20-day history of headaches and bilateral lower limb weakness for 10 days. Physical examination revealed slow and unsteady gait. An occupying lesion was observed in the right frontal-temporal-parietal region of the skull on the Cranial imaging. A right cranial bone tumor margin expansion resection was performed. The patient\'s motor functions recovered normally after surgery. Postoperative imaging examinations showed10 tumor resection. Follow-up imaging examinations showed tumor recurrence. The patient underwent resection of the recurrent tumor. Postoperative pathological analysis revealed malignant transformation of the AM.Follow-up imaging examinations showed tumor recurrence again. The patient was admitted for stereotactic radiotherapy. Follow-up imaging examinations demonstrated no evidence of tumor recurrence and subsequent chest CT revealed no signs of metastasis.
UNASSIGNED: Primary AM or AMCa of the skull is increasingly being described in the literature, but detailed reports on the malignant transformation of primary AM of the skull are lacking. The pathogenesis of this condition remains unclear. Aggressive treatment and close follow-up may be crucial for preventing disease recurrence and malignant transformation.
摘要：
■自1964年以来，颅骨原发性成釉细胞瘤（AM）或成釉细胞癌（AMCa）的报道病例很少。这种罕见情况在特定解剖部位的临床表现和独特特征仍不清楚。我们报告了一例位于额颞叶顶叶区域的颅骨原发性AM恶性转化的病例，并强调了其与文献中报道的其他病例的相似性。
■一名53岁女性患者，有20天的头痛和10天的双侧下肢无力病史。体格检查显示步态缓慢且不稳定。在颅骨成像上，在颅骨的右额叶-颞叶-顶叶区域观察到占位性病变。行右颅骨肿瘤边缘扩张切除术。手术后患者的运动功能恢复正常。术后影像学检查显示10例肿瘤切除。随访影像学检查显示肿瘤复发。患者接受了复发性肿瘤的切除术。术后病理分析显示AM恶变。随访影像学检查显示肿瘤复发。患者接受立体定向放疗。随访影像学检查显示没有肿瘤复发的证据，随后的胸部CT显示没有转移的迹象。
■颅骨的初级AM或AMCa在文献中越来越多地被描述，但是缺乏有关颅骨原发性AM恶性转化的详细报道。这种情况的发病机制尚不清楚。积极的治疗和密切的随访可能是预防疾病复发和恶变的关键。
■一名53岁女性患者，有20天的头痛和10天的双侧下肢无力病史。体格检查显示步态缓慢且不稳定。在颅骨成像上，在颅骨的右额叶-颞叶-顶叶区域观察到占位性病变。行右颅骨肿瘤边缘扩张切除术。手术后患者的运动功能恢复正常。术后影像学检查显示10例肿瘤切除。随访影像学检查显示肿瘤复发。患者接受了复发性肿瘤的切除术。术后病理分析显示AM恶变。随访影像学检查显示肿瘤复发。患者接受立体定向放疗。随访影像学检查显示没有肿瘤复发的证据，随后的胸部CT显示没有转移的迹象。
■颅骨的初级AM或AMCa在文献中越来越多地被描述，但是缺乏有关颅骨原发性AM恶性转化的详细报道。这种情况的发病机制尚不清楚。积极的治疗和密切的随访可能是预防疾病复发和恶变的关键。
