PDF(Pubmed)
Abstract：
Physical activity (PA) is beneficial for the overall health. Objectives are: (1) To compare metabolic (MRM) and cardiovascular-risk-markers (CRM) in children according to their PA-level; (2) to explore the associations of MRM and CRM with PA and sedentary time (ST); and (3) to identify the associations between MRM and CRM in less (LA) and more active (MA) children.
A total of 238 apparently healthy school-aged children were enrolled (132 boys/106 girls; 9.1 ± 1.8 years) and body mass index standard deviation score (BMI SDS) and blood pressure were assessed. Fasting venous blood sampling was performed to assess insulin resistance (HOMA-IR) and high-sensitivity-C-reactive protein (hsCRP). Epicardial fat, interventricular septal and left ventricular posterior wall thicknesses were assessed by high-resolution ultrasonography. PA and ST were assessed by enKid-questionnaire. Children were classified based on enKid-score as being LA and MA (below and above 50th percentile for PA).
MA-children had lower values for: BMI SDS, diastolic-to-systolic blood pressure ratio, HOMA-IR and hsCRP (7.02 to 61.5% lower, p = 0.040 to p < 0.0001) compared to LA-children. MRM and CRM were positively associated with ST (p = 0.003 to p < 0.001), and negatively associated with PA (p = 0.044 to p < 0.001). Finally, MRM were positively associated with CRM (p = 0.008 to p < 0.0001). Interestingly, the latter associations were observed in LA-children but were not present in MA-children.
More PA is associated with better cardio-metabolic profile in school-aged children. PA seems to modulate the associations between MRM and CRM, thus reinforcing the idea that fostering PA in children may lower the risk for development of a cardio-metabolic disease.
A total of 238 apparently healthy school-aged children were enrolled (132 boys/106 girls; 9.1 ± 1.8 years) and body mass index standard deviation score (BMI SDS) and blood pressure were assessed. Fasting venous blood sampling was performed to assess insulin resistance (HOMA-IR) and high-sensitivity-C-reactive protein (hsCRP). Epicardial fat, interventricular septal and left ventricular posterior wall thicknesses were assessed by high-resolution ultrasonography. PA and ST were assessed by enKid-questionnaire. Children were classified based on enKid-score as being LA and MA (below and above 50th percentile for PA).
MA-children had lower values for: BMI SDS, diastolic-to-systolic blood pressure ratio, HOMA-IR and hsCRP (7.02 to 61.5% lower, p = 0.040 to p < 0.0001) compared to LA-children. MRM and CRM were positively associated with ST (p = 0.003 to p < 0.001), and negatively associated with PA (p = 0.044 to p < 0.001). Finally, MRM were positively associated with CRM (p = 0.008 to p < 0.0001). Interestingly, the latter associations were observed in LA-children but were not present in MA-children.
More PA is associated with better cardio-metabolic profile in school-aged children. PA seems to modulate the associations between MRM and CRM, thus reinforcing the idea that fostering PA in children may lower the risk for development of a cardio-metabolic disease.
摘要：
■体力活动（PA）对整体健康有益。目标是：（1）根据儿童的PA水平比较儿童的代谢（MRM）和心血管风险标志物（CRM）；（2）探讨MRM和CRM与PA和久坐时间（ST）的相关性；（3）确定较少（LA）和较活跃（MA）儿童的MRM和CRM之间的关联。
■共纳入238名明显健康的学龄儿童（132名男孩/106名女孩；9.1±1.8岁），并评估体重指数标准差评分（BMISDS）和血压。空腹静脉采血以评估胰岛素抵抗（HOMA-IR）和高敏C反应蛋白（hsCRP）。心外膜脂肪,通过高分辨率超声检查评估室间隔和左心室后壁的厚度.PA和ST通过enKid问卷进行评估。根据enKid评分将儿童分为LA和MA（PA低于和高于50百分位数）。
■MA儿童的BMISDS值较低，舒张压与收缩压的比值,HOMA-IR和hsCRP（降低7.02至61.5%，与LA儿童相比，p=0.040至p<0.0001）。MRM和CRM与ST呈正相关（p=0.003至p<0.001），与PA呈负相关(p=0.044至p<0.001)。最后,MRM与CRM呈正相关(p=0.008至p<0.0001)。有趣的是,后一种关联在LA儿童中观察到,但在MA儿童中不存在.
■更多的PA与学龄儿童更好的心脏代谢特征相关。PA似乎调节MRM和CRM之间的关联，因此，强化了在儿童中培养PA可能降低心脏代谢性疾病发展风险的观点。
■共纳入238名明显健康的学龄儿童（132名男孩/106名女孩；9.1±1.8岁），并评估体重指数标准差评分（BMISDS）和血压。空腹静脉采血以评估胰岛素抵抗（HOMA-IR）和高敏C反应蛋白（hsCRP）。心外膜脂肪,通过高分辨率超声检查评估室间隔和左心室后壁的厚度.PA和ST通过enKid问卷进行评估。根据enKid评分将儿童分为LA和MA（PA低于和高于50百分位数）。
■MA儿童的BMISDS值较低，舒张压与收缩压的比值,HOMA-IR和hsCRP（降低7.02至61.5%，与LA儿童相比，p=0.040至p<0.0001）。MRM和CRM与ST呈正相关（p=0.003至p<0.001），与PA呈负相关(p=0.044至p<0.001)。最后,MRM与CRM呈正相关(p=0.008至p<0.0001)。有趣的是,后一种关联在LA儿童中观察到,但在MA儿童中不存在.
■更多的PA与学龄儿童更好的心脏代谢特征相关。PA似乎调节MRM和CRM之间的关联，因此，强化了在儿童中培养PA可能降低心脏代谢性疾病发展风险的观点。
