PDF(Pubmed)
Abstract：
BACKGROUND: Chronic lung disease of prematurity (CLD) is the most prevalent complication of preterm birth and indicates an increased likelihood of long-term pulmonary complications. The accurate diagnosis of this condition is critical for long-term health management. Numerous definitions define CLD with different clinical parameters and radiology findings, making diagnosis of the disease ambiguous and potentially inaccurate.
METHODS: 95 patients were identified for this study, as determined by the diagnosis or confirmation of CLD in the impression of the radiologist\'s report on chest x-ray. Pulmonary function and complications were recorded at multiple benchmark timeframes within each patient\'s first few months of life and used for determining eligibility under each definition.
RESULTS: Each clinical definition of CLD had a high sensitivity for patients identified to have CLD by radiologists, correctly fitting over 90% of patients. Most patients included required invasive mechanical ventilation or positive pressure ventilation at 36 weeks postmenstrual age, indicating patients with radiographically confirmed CLD tended to have more severe disease. Radiologists tended to diagnose CLD before 36 weeks postmenstrual age, a timepoint used by multiple standard clinical definitions, with cases called earlier fitting under a larger percentage of definitions than those called later.
CONCLUSIONS: Radiologists tend to diagnose CLD in young patients with severe respiratory compromise, and can accurately diagnose the condition before developmental milestones for clinical definitions are met.
METHODS: 95 patients were identified for this study, as determined by the diagnosis or confirmation of CLD in the impression of the radiologist\'s report on chest x-ray. Pulmonary function and complications were recorded at multiple benchmark timeframes within each patient\'s first few months of life and used for determining eligibility under each definition.
RESULTS: Each clinical definition of CLD had a high sensitivity for patients identified to have CLD by radiologists, correctly fitting over 90% of patients. Most patients included required invasive mechanical ventilation or positive pressure ventilation at 36 weeks postmenstrual age, indicating patients with radiographically confirmed CLD tended to have more severe disease. Radiologists tended to diagnose CLD before 36 weeks postmenstrual age, a timepoint used by multiple standard clinical definitions, with cases called earlier fitting under a larger percentage of definitions than those called later.
CONCLUSIONS: Radiologists tend to diagnose CLD in young patients with severe respiratory compromise, and can accurately diagnose the condition before developmental milestones for clinical definitions are met.
摘要：
背景：早产儿慢性肺病（CLD）是早产最常见的并发症，表明长期肺部并发症的可能性增加。这种情况的准确诊断对于长期健康管理至关重要。许多定义定义了具有不同临床参数和放射学结果的CLD，使疾病的诊断含糊不清和潜在的不准确。
方法：本研究确定了95例患者，根据放射科医师胸片报告中CLD的诊断或确认确定。在每个患者生命的最初几个月内，在多个基准时间范围内记录肺功能和并发症，并用于确定每个定义下的资格。
结果：CLD的每个临床定义对于放射科医师确定患有CLD的患者都有很高的敏感性，正确拟合超过90％的患者。大多数患者在月经后36周时需要有创机械通气或正压通气，表明放射学证实的CLD患者倾向于患有更严重的疾病。放射科医生倾向于在月经后36周之前诊断CLD，多个标准临床定义使用的时间点，与较早调用的情况相比，在更大的定义百分比下拟合。
结论：放射科医师倾向于在患有严重呼吸损害的年轻患者中诊断CLD，并且可以在满足临床定义的发展里程碑之前准确诊断病情。
方法：本研究确定了95例患者，根据放射科医师胸片报告中CLD的诊断或确认确定。在每个患者生命的最初几个月内，在多个基准时间范围内记录肺功能和并发症，并用于确定每个定义下的资格。
结果：CLD的每个临床定义对于放射科医师确定患有CLD的患者都有很高的敏感性，正确拟合超过90％的患者。大多数患者在月经后36周时需要有创机械通气或正压通气，表明放射学证实的CLD患者倾向于患有更严重的疾病。放射科医生倾向于在月经后36周之前诊断CLD，多个标准临床定义使用的时间点，与较早调用的情况相比，在更大的定义百分比下拟合。
结论：放射科医师倾向于在患有严重呼吸损害的年轻患者中诊断CLD，并且可以在满足临床定义的发展里程碑之前准确诊断病情。
