PDF(Pubmed)
Abstract：
Lower limb varicose veins are a prevalent disease associated with several available treatment options, including conventional surgery and polidocanol foam sclerotherapy. However, few studies have analyzed therapeutic modality outcomes based on Patient-Reported Outcome Measures (PROMs). This large sample-size study was designed to evaluate the outcomes of polidocanol foam sclerotherapy compared to conventional surgery based on an analysis of PROMs.
This was a prospective, observational, and qualitative study of 205 patients who underwent varicose vein treatment with either polidocanol foam sclerotherapy (57 patients, 90 legs) or conventional surgery (148 patients, 236 legs). Patients were preoperatively assessed and re-evaluated 30 days after the procedure using the Venous Disease Severity Score (VCSS) and specific venous disease quality-of-life questionnaires (VEINES-QoL/Sym).
Both treatments significantly improved VCSS and VEINES results 30 days after the procedure (p < 0.05). However, surgery promoted greater improvements in VCSS (on average 4.02-points improvement, p < 0.001), VEINES-QoL (average 8-points improvement, p < 0.001), and VEINES-Sym (average 11.66 points improvement, p < 0.001) than did sclerotherapy. Postoperative pain and aesthetic concerns about the legs were the domains of the questionnaires in which the results varied the most between the treatment modalities, with worse results for sclerotherapy.
Both polidocanol foam sclerotherapy and conventional surgery positively impact patients\' quality of life after 30 days, but the improvement is more significant for patients who undergo conventional surgery.
This was a prospective, observational, and qualitative study of 205 patients who underwent varicose vein treatment with either polidocanol foam sclerotherapy (57 patients, 90 legs) or conventional surgery (148 patients, 236 legs). Patients were preoperatively assessed and re-evaluated 30 days after the procedure using the Venous Disease Severity Score (VCSS) and specific venous disease quality-of-life questionnaires (VEINES-QoL/Sym).
Both treatments significantly improved VCSS and VEINES results 30 days after the procedure (p < 0.05). However, surgery promoted greater improvements in VCSS (on average 4.02-points improvement, p < 0.001), VEINES-QoL (average 8-points improvement, p < 0.001), and VEINES-Sym (average 11.66 points improvement, p < 0.001) than did sclerotherapy. Postoperative pain and aesthetic concerns about the legs were the domains of the questionnaires in which the results varied the most between the treatment modalities, with worse results for sclerotherapy.
Both polidocanol foam sclerotherapy and conventional surgery positively impact patients\' quality of life after 30 days, but the improvement is more significant for patients who undergo conventional surgery.
摘要：
目的：下肢静脉曲张是一种常见的疾病，与几种可用的治疗方案有关，包括常规手术和脊髓灰质炎泡沫硬化剂治疗。然而,很少有研究根据患者报告的结局指标(PROMs)分析治疗方式结局.这项大样本量研究的目的是根据对PROMs的分析，评估与传统手术相比，使用脊髓灰质炎泡沫硬化剂治疗的结果。
方法：这是一个前瞻性的，观察,和定性研究的205例患者谁接受了静脉曲张治疗与任一脊髓灰质炎醇泡沫硬化（57例患者，90条腿）或常规手术（148名患者，236条腿）。术前评估患者并在手术后30天使用静脉疾病严重程度评分（VCSS）和特定静脉疾病生活质量问卷（VEINES-QoL/Sym）进行重新评估。
结果:两种治疗在手术后30天显著改善了VCSS和VEINES结果(p<0.05)。然而,手术促进了VCSS的更大改善(平均改善4.02分，p<0.001)，VEINES-QoL（平均提高8分，p<0.001)，和VEINES-Sym(平均提高11.66分，p<0.001）比硬化疗法。术后疼痛和对腿部的美学关注是问卷的领域，其中结果在治疗方式之间差异最大。硬化治疗效果较差.
结论：脊髓灰质炎醇泡沫硬化剂治疗和常规手术均对患者30天后的生活质量产生积极影响，但对于接受传统手术的患者来说，这种改善更为显著。
方法：这是一个前瞻性的，观察,和定性研究的205例患者谁接受了静脉曲张治疗与任一脊髓灰质炎醇泡沫硬化（57例患者，90条腿）或常规手术（148名患者，236条腿）。术前评估患者并在手术后30天使用静脉疾病严重程度评分（VCSS）和特定静脉疾病生活质量问卷（VEINES-QoL/Sym）进行重新评估。
结果:两种治疗在手术后30天显著改善了VCSS和VEINES结果(p<0.05)。然而,手术促进了VCSS的更大改善(平均改善4.02分，p<0.001)，VEINES-QoL（平均提高8分，p<0.001)，和VEINES-Sym(平均提高11.66分，p<0.001）比硬化疗法。术后疼痛和对腿部的美学关注是问卷的领域，其中结果在治疗方式之间差异最大。硬化治疗效果较差.
结论：脊髓灰质炎醇泡沫硬化剂治疗和常规手术均对患者30天后的生活质量产生积极影响，但对于接受传统手术的患者来说，这种改善更为显著。
