Abstract：
OBJECTIVE: The aim of this study was to analyze the effectiveness of L-PRF as a healing agent in the postoperative period of third molar extraction surgeries, as well as to investigate secondary effects, such as the reduction of pain, edema and other discomforts after the surgical intervention.
METHODS: The methodology adopted consisted of carrying out a systematic review of the literature, following the model outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The inclusion criteria were previously established according to a systematic review protocol approved by the Prospective Register of Systematic Reviews (PROSPERO) under number CRD42023484679. In order to carry out a comprehensive search, a search in five databases was carried out, PubMed, Web of Science, Scopus, Cochrane Library and Embase.
RESULTS: The search resulted in the selection of randomized controlled trials that conformed to the established criteria. Two authors independently screened the records and extracted the data. The assessment of bias was conducted according to the guidelines recommended by the Cochrane Collaboration, using version 2 of the Cochrane tool for assessing the risk of bias in randomized trials (RoB 2).
CONCLUSIONS: This study demonstrated that L-PRF stands out by providing direct benefits to healing, vascularization and tissue regeneration.
CONCLUSIONS: L-PRF plays an important role in reducing postoperative pain, edema, the incidence of alveolar osteitis and infections after third molar removal surgery, compared to patients who did not undergo the use of L-PRF.
METHODS: The methodology adopted consisted of carrying out a systematic review of the literature, following the model outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The inclusion criteria were previously established according to a systematic review protocol approved by the Prospective Register of Systematic Reviews (PROSPERO) under number CRD42023484679. In order to carry out a comprehensive search, a search in five databases was carried out, PubMed, Web of Science, Scopus, Cochrane Library and Embase.
RESULTS: The search resulted in the selection of randomized controlled trials that conformed to the established criteria. Two authors independently screened the records and extracted the data. The assessment of bias was conducted according to the guidelines recommended by the Cochrane Collaboration, using version 2 of the Cochrane tool for assessing the risk of bias in randomized trials (RoB 2).
CONCLUSIONS: This study demonstrated that L-PRF stands out by providing direct benefits to healing, vascularization and tissue regeneration.
CONCLUSIONS: L-PRF plays an important role in reducing postoperative pain, edema, the incidence of alveolar osteitis and infections after third molar removal surgery, compared to patients who did not undergo the use of L-PRF.
摘要：
目的：本研究的目的是分析在第三磨牙拔除手术后，L-PRF作为愈合剂的有效性，以及调查次要影响，比如减轻疼痛，手术干预后的水肿和其他不适。
方法：采用的方法包括对文献进行系统回顾，遵循系统审查和荟萃分析的首选报告项目(PRISMA)概述的模型。纳入标准先前是根据前瞻性系统审查登记册（PROSPERO）批准的系统审查方案建立的，编号为CRD42023484679。为了进行全面的搜索，在五个数据库中进行了搜索，PubMed,WebofScience,Scopus,Cochrane图书馆和Embase。
结果：搜索结果选择了符合既定标准的随机对照试验。两位作者独立筛选记录并提取数据。偏见的评估是根据Cochrane合作组织推荐的指南进行的，使用Cochrane工具的第2版评估随机试验中的偏倚风险(RoB2)。
结论：这项研究表明，L-PRF通过为愈合提供直接益处而脱颖而出，血管化和组织再生。
结论：L-PRF在减轻术后疼痛中起重要作用，水肿,第三磨牙摘除手术后牙槽骨炎和感染的发生率，与未使用L-PRF的患者相比。
方法：采用的方法包括对文献进行系统回顾，遵循系统审查和荟萃分析的首选报告项目(PRISMA)概述的模型。纳入标准先前是根据前瞻性系统审查登记册（PROSPERO）批准的系统审查方案建立的，编号为CRD42023484679。为了进行全面的搜索，在五个数据库中进行了搜索，PubMed,WebofScience,Scopus,Cochrane图书馆和Embase。
结果：搜索结果选择了符合既定标准的随机对照试验。两位作者独立筛选记录并提取数据。偏见的评估是根据Cochrane合作组织推荐的指南进行的，使用Cochrane工具的第2版评估随机试验中的偏倚风险(RoB2)。
结论：这项研究表明，L-PRF通过为愈合提供直接益处而脱颖而出，血管化和组织再生。
结论：L-PRF在减轻术后疼痛中起重要作用，水肿,第三磨牙摘除手术后牙槽骨炎和感染的发生率，与未使用L-PRF的患者相比。
