PDF(Pubmed)
Abstract：
Most of vaccinees and COVID-19 convalescents can build effective anti-SARS-CoV-2 humoral immunity, which helps preventing infection and alleviating symptoms. However, breakthrough viral infections caused by emerging SARS-CoV-2 variants, especially Omicron subvariants, still pose a serious threat to global health. By monitoring the viral infections and the sera neutralization ability of a long-tracked cohort, we found out that the immune evasion of emerging Omicron subvariants and the decreasing neutralization led to the mini-wave of SARS-CoV-2 breakthrough infections. Meanwhile, no significant difference had been found in the infectivity of tested SARS-CoV-2 variants, even though the affinity between human angiotensin-converting enzyme 2 (hACE2) and receptor-binding domain (RBDs) of tested variants showed an increasing trend. Notably, the immune imprinting of inactivated COVID-19 vaccine can be relieved by infections of BA.5.2 and XBB.1.5 variants sequentially. Our data reveal the rising reinfection risk of immune evasion variants like Omicron JN.1 in China, suggesting the importance of booster with updated vaccines.
摘要：
大多数疫苗接种者和COVID-19疗养者可以建立有效的抗SARS-CoV-2体液免疫，这有助于预防感染和缓解症状。然而,由新出现的SARS-CoV-2变种引起的突破性病毒感染，尤其是Omicron亚变体，仍然对全球健康构成严重威胁。通过监测长期跟踪队列的病毒感染和血清中和能力，我们发现，新出现的Omicron亚变体的免疫逃避和中和作用的降低导致了SARS-CoV-2突破性感染的小波。同时,在测试的SARS-CoV-2变体的传染性方面没有发现显着差异，尽管人血管紧张素转换酶2（hACE2）与受试变体的受体结合域（RBD）之间的亲和力呈上升趋势。值得注意的是,灭活COVID-19疫苗的免疫印记可以通过依次感染BA.5.2和XBB1.5变体来缓解。我们的数据显示，在中国，OmicronJN.1等免疫逃避变异的再感染风险正在上升，提示用更新的疫苗加强的重要性。
