PDF(Pubmed)
Abstract：
Diabetic nephropathy (DN) is a severe complication of diabetes, characterized by changes in kidney structure and function. The natural product rosmarinic acid (RA) has demonstrated therapeutic effects, including anti-inflammation and anti-oxidative-stress, in renal damage or dysfunction. In this study, we characterized the heterogeneity of the cellular response in kidneys to DN-induced injury and RA treatment at single cell levels. Our results demonstrated that RA significantly alleviated renal tubular epithelial injury, particularly in the proximal tubular S1 segment and on glomerular epithelial cells known as podocytes, while attenuating the inflammatory response of macrophages, oxidative stress, and cytotoxicity of natural killer cells. These findings provide a comprehensive understanding of the mechanisms by which RA alleviates kidney damage, oxidative stress, and inflammation, offering valuable guidance for the clinical application of RA in the treatment of DN.
摘要：
糖尿病肾病(DN)是糖尿病的严重并发症,以肾脏结构和功能变化为特征。天然产物迷迭香酸（RA）已显示出治疗效果，包括抗炎和抗氧化应激，在肾损害或功能障碍。在这项研究中,我们在单细胞水平表征了肾脏对DN诱导的损伤和RA治疗的细胞反应的异质性.我们的结果表明，RA可显着减轻肾小管上皮损伤，特别是在近端肾小管S1段和称为足细胞的肾小球上皮细胞上，同时减弱巨噬细胞的炎症反应，氧化应激，和自然杀伤细胞的细胞毒性。这些发现提供了对RA减轻肾脏损害的机制的全面理解。氧化应激，和炎症，为RA在DN治疗中的临床应用提供了有价值的指导。
