Abstract：
Cushing\'s syndrome (CS) is a complex disorder characterized by the excessive secretion of cortisol, with Cushing\'s disease (CD), particularly associated with pituitary tumors, exhibiting heightened morbidity and mortality. Although transsphenoidal pituitary surgery (TSS) stands as the primary treatment for CD, there is a crucial need to optimize patient prognosis. Current medical therapy serves as an adjunctive measure due to its unsatisfactory efficacy and unpredictable side effects. In this comprehensive review, we delve into recent advances in understanding the pathogenesis of CS and explore therapeutic options by conducting a critical analysis of potential drug targets and candidates. Additionally, we provide an overview of the design strategy employed in previously reported candidates, along with a summary of structure-activity relationship (SAR) analyses and their biological efficacy. This review aims to contribute valuable insights to the evolving landscape of CS research, shedding light on potential avenues for therapeutic development.
摘要：
库欣综合征（CS）是一种复杂的疾病，其特征是皮质醇分泌过多，患有库欣病（CD），特别是与垂体瘤有关，表现出更高的发病率和死亡率。尽管经蝶窦垂体手术（TSS）是CD的主要治疗方法，因此,优化患者预后至关重要.由于其不令人满意的功效和不可预测的副作用,目前的药物治疗作为辅助措施。在这次全面审查中，我们通过对潜在的药物靶点和候选药物进行批判性分析,深入研究CS发病机制方面的最新进展,并探索治疗方案.此外,我们概述了以前报告的候选人采用的设计策略，以及结构-活性关系（SAR）分析及其生物学功效的总结。这篇综述旨在为CS研究的发展提供有价值的见解，揭示治疗发展的潜在途径。
