Abstract：
Toxoplasma gondii is a ubiquitous parasitic protozoan that may be an important cause of neurological and psychiatric diseases. The purpose of this case-control registry-based study was to evaluate the prevalence of T. gondii infection and related risk factors among subjects who attempted suicide by drug use and a control group at the Iranian National Registry Center for Toxoplasmosis in Mazandaran Province, northern Iran. Baseline data were collected from participants using a questionnaire, and a blood sample was taken from each individual. The plasma was prepared for serological analysis, whereas the buffy coat was used for molecular analysis. Out of 282 individuals (147 cases with suicide attempters [SA] and 135 controls), 42.9% of patients and 16.3% of control subjects were positive for anti-Toxoplasma immunoglobin G (IgG), but all participants were negative for T. gondii DNA and anti-Toxoplasma immunoglobin M. Based on multiple logistic regressions, IgG seropositivity in SA in the age group of 20-30 years was 3.22 times higher than that in the control group (p < 0.001). These findings suggest that latent T. gondii infection among SA is significantly higher than that in healthy individuals, indicating a potential association between latent toxoplasmosis and SA at least in the studied area. Further research is needed to shed light on the potential association between T. gondii and suicide among different populations and areas of the world.
摘要：
弓形虫是一种普遍存在的寄生原虫，可能是神经和精神疾病的重要原因。这项基于病例对照登记的研究的目的是评估在马赞达兰省伊朗国家弓形虫病登记中心通过吸毒企图自杀的受试者和对照组中弓形虫感染的患病率和相关危险因素，伊朗北部。基线数据是使用问卷从参与者那里收集的，并从每个人身上采集血液样本。血浆准备用于血清学分析，而血沉棕黄层用于分子分析。在282个人中（147例自杀未遂[SA]和135例对照），42.9%的患者和16.3%的对照受试者抗弓形虫免疫球蛋白G(IgG)阳性,但所有参与者的弓形虫DNA和抗弓形虫免疫球蛋白M均为阴性。20-30岁年龄组中SA的IgG血清阳性率是对照组的3.22倍（p<0.001）。这些发现表明，SA中潜伏性弓形虫感染明显高于健康个体，至少在研究区域，表明潜在弓形虫病与SA之间存在潜在关联。需要进一步的研究来阐明弓形虫与世界不同人群和地区之间自杀之间的潜在联系。
