PDF(Pubmed)
Abstract：
UNASSIGNED: It is unknown whether maintaining normal blood pressure (BP) from middle to older age is associated with improved health outcomes.
UNASSIGNED: We estimated the proportion of Atherosclerosis Risk in Communities study participants who maintained normal BP from 1987 to 1989 (visit 1) through 1996 to 1998 and 2011 to 2013 (over 4 and 5 visits, respectively). Normal BP was defined as systolic BP <120 mm Hg and diastolic BP <80 mm Hg, without antihypertensive medication. We estimated the risk of cardiovascular disease, dementia, and poor physical functioning after visit 5. In exploratory analyses, we examined participant characteristics associated with maintaining normal BP.
UNASSIGNED: Among 2699 participants with normal BP at baseline (mean age 51.3 years), 47.1% and 15.0% maintained normal BP through visits 4 and 5, respectively. The hazard ratios comparing participants who maintained normal BP through visit 4 but not visit 5 and through visit 5 versus those who did not maintain normal BP through visit 4 were 0.80 (95% CI, 0.63-1.03) and 0.60 (95% CI, 0.42-0.86), respectively, for cardiovascular disease, and 0.85 (95% CI, 0.71-1.01) and 0.69 (95% CI, 0.54-0.90), respectively, for poor physical functioning. Maintaining normal BP through visit 5 was more common among participants with normal body mass index versus obesity at visit 1, those with normal body mass index at visits 1 and 5, and those with overweight at visit 1 and overweight or normal body mass index at visit 5, compared with those with obesity at visits 1 and 5.
UNASSIGNED: Maintaining normal BP was associated with a lower risk of cardiovascular disease and poor physical functioning.
UNASSIGNED: We estimated the proportion of Atherosclerosis Risk in Communities study participants who maintained normal BP from 1987 to 1989 (visit 1) through 1996 to 1998 and 2011 to 2013 (over 4 and 5 visits, respectively). Normal BP was defined as systolic BP <120 mm Hg and diastolic BP <80 mm Hg, without antihypertensive medication. We estimated the risk of cardiovascular disease, dementia, and poor physical functioning after visit 5. In exploratory analyses, we examined participant characteristics associated with maintaining normal BP.
UNASSIGNED: Among 2699 participants with normal BP at baseline (mean age 51.3 years), 47.1% and 15.0% maintained normal BP through visits 4 and 5, respectively. The hazard ratios comparing participants who maintained normal BP through visit 4 but not visit 5 and through visit 5 versus those who did not maintain normal BP through visit 4 were 0.80 (95% CI, 0.63-1.03) and 0.60 (95% CI, 0.42-0.86), respectively, for cardiovascular disease, and 0.85 (95% CI, 0.71-1.01) and 0.69 (95% CI, 0.54-0.90), respectively, for poor physical functioning. Maintaining normal BP through visit 5 was more common among participants with normal body mass index versus obesity at visit 1, those with normal body mass index at visits 1 and 5, and those with overweight at visit 1 and overweight or normal body mass index at visit 5, compared with those with obesity at visits 1 and 5.
UNASSIGNED: Maintaining normal BP was associated with a lower risk of cardiovascular disease and poor physical functioning.
摘要：
■尚不清楚从中年到老年保持正常血压（BP）是否与改善健康状况有关。
■我们估计了从1987年至1989年（第1次访问）到1996年至1998年和2011年至2013年（超过4次和5次访问，维持正常血压的社区研究参与者中动脉粥样硬化风险的比例，分别)。正常血压定义为收缩压<120mmHg和舒张压<80mmHg，没有抗高血压药物。我们估计了心血管疾病的风险，痴呆症,访问5后身体机能差。在探索性分析中，我们检查了与维持正常BP相关的参与者特征.
■在基线血压正常的2699名参与者中（平均年龄51.3岁），47.1％和15.0％分别通过第4次和第5次随访维持正常BP。通过第4次访视但第5次访视和第5次访视维持正常血压的参与者与第4次访视未维持正常血压的参与者的风险比分别为0.80（95％CI，0.63-1.03）和0.60（95％CI，0.42-0.86）。分别,心血管疾病，和0.85（95%CI，0.71-1.01）和0.69（95%CI，0.54-0.90），分别,身体机能差。在第1次就诊时体重指数正常与肥胖的参与者，第1次和第5次就诊时体重指数正常的参与者，第1次和第5次就诊时体重指数正常的参与者，以及第1次就诊时体重超重或体重指数正常的参与者，第5次就诊时与第1次和第5次就诊时肥胖的参与者相比，更常见。
■维持正常血压与心血管疾病风险较低和身体机能不良相关。
■我们估计了从1987年至1989年（第1次访问）到1996年至1998年和2011年至2013年（超过4次和5次访问，维持正常血压的社区研究参与者中动脉粥样硬化风险的比例，分别)。正常血压定义为收缩压<120mmHg和舒张压<80mmHg，没有抗高血压药物。我们估计了心血管疾病的风险，痴呆症,访问5后身体机能差。在探索性分析中，我们检查了与维持正常BP相关的参与者特征.
■在基线血压正常的2699名参与者中（平均年龄51.3岁），47.1％和15.0％分别通过第4次和第5次随访维持正常BP。通过第4次访视但第5次访视和第5次访视维持正常血压的参与者与第4次访视未维持正常血压的参与者的风险比分别为0.80（95％CI，0.63-1.03）和0.60（95％CI，0.42-0.86）。分别,心血管疾病，和0.85（95%CI，0.71-1.01）和0.69（95%CI，0.54-0.90），分别,身体机能差。在第1次就诊时体重指数正常与肥胖的参与者，第1次和第5次就诊时体重指数正常的参与者，第1次和第5次就诊时体重指数正常的参与者，以及第1次就诊时体重超重或体重指数正常的参与者，第5次就诊时与第1次和第5次就诊时肥胖的参与者相比，更常见。
■维持正常血压与心血管疾病风险较低和身体机能不良相关。
