PDF(Pubmed)
Abstract：
UNASSIGNED: Capecitabine has rarely been associated with neurotoxicity. Cerebellar ataxia, multifocal leukoencephalopathy, and sensorimotor peripheral neuropathy have been reported in the literature. A case of 6th nerve palsy associated with capecitabine has also been described. This article reports the first case of capecitabine-related 4th nerve palsy.
UNASSIGNED: A 72-year-old Caucasian woman was referred by the Oncology Department because she had been complaining of binocular diplopia for 6 months. The symptoms started 1 month after the introduction of capecitabine. A diagnosis of right 4th nerve palsy was made using the Parks three-step test and the Hess test. Neuroimaging analysis was negative. A slow but progressive deterioration of function was confirmed during a year of follow-up. On suspicion of a chemotherapy-related palsy, capecitabine was discontinued and switched to vinorelbine. Subsequent improvement of the clinical picture was confirmed within 2 months.
UNASSIGNED: The recognition of chemotherapy-related neurotoxicity is of paramount importance in the management of oncology patients. Once secondary invasion of the brain or the orbit by the tumor itself is ruled out, it must be suspected to prevent further deterioration.
UNASSIGNED: A 72-year-old Caucasian woman was referred by the Oncology Department because she had been complaining of binocular diplopia for 6 months. The symptoms started 1 month after the introduction of capecitabine. A diagnosis of right 4th nerve palsy was made using the Parks three-step test and the Hess test. Neuroimaging analysis was negative. A slow but progressive deterioration of function was confirmed during a year of follow-up. On suspicion of a chemotherapy-related palsy, capecitabine was discontinued and switched to vinorelbine. Subsequent improvement of the clinical picture was confirmed within 2 months.
UNASSIGNED: The recognition of chemotherapy-related neurotoxicity is of paramount importance in the management of oncology patients. Once secondary invasion of the brain or the orbit by the tumor itself is ruled out, it must be suspected to prevent further deterioration.
摘要：
■卡培他滨很少与神经毒性相关。小脑共济失调,多灶性白质脑病,和感觉运动周围神经病变已在文献中报道。还描述了与卡培他滨相关的第六神经麻痹病例。本文报告首例卡培他滨相关性第四神经麻痹。
一名72岁的白人女性因主诉双眼复视6个月而被肿瘤科转诊。该症状在引入卡培他滨1个月后开始。使用Parks三步测试和Hess测试诊断右第四神经麻痹。神经影像学分析为阴性。在一年的随访中证实了功能的缓慢但进行性恶化。怀疑化疗相关的麻痹,卡培他滨停药，改用长春瑞滨。随后在2个月内证实了临床表现的改善。
■认识到化疗相关的神经毒性在肿瘤患者的管理中至关重要。一旦排除了肿瘤本身对大脑或眼眶的继发性侵袭，必须怀疑这一点，以防止进一步恶化。
一名72岁的白人女性因主诉双眼复视6个月而被肿瘤科转诊。该症状在引入卡培他滨1个月后开始。使用Parks三步测试和Hess测试诊断右第四神经麻痹。神经影像学分析为阴性。在一年的随访中证实了功能的缓慢但进行性恶化。怀疑化疗相关的麻痹,卡培他滨停药，改用长春瑞滨。随后在2个月内证实了临床表现的改善。
■认识到化疗相关的神经毒性在肿瘤患者的管理中至关重要。一旦排除了肿瘤本身对大脑或眼眶的继发性侵袭，必须怀疑这一点，以防止进一步恶化。
