PDF(Pubmed)
Abstract：
The epidemiological and clinical aspects of Human Papillomavirus (HPV) infection in women have been extensively studied. However, there is a lack of information regarding HPV characteristics in males. In this study, we conducted a retrospective and observational study of 3737 consecutive male individuals attending outpatient clinics of Guangdong Women and Children Hospital from 2012 to 2023 in Guangzhou, South China, to determine the age- and genotype-specific prevalence of HPV in men. The results showed the overall prevalence of HPV among men was 42.15% (1575/3737), with variations ranging from 29.55% to 81.31% across distinct diagnostic populations. Low-risk HPV6 (15.47%), HPV11 (8.94%), and high-risk HPV52 (5.51%) were the most common types. The annual HPV prevalence decreased significantly (Z = -3.882, p < .001), ranging from 31.44% to 52.90%. 28.77% (1075/3737) of men manifested infection with a singular HPV type, predominantly identified as a low-risk type. The age-specific distribution of HPV infections revealed distinctive peaks in the < 25 y age group (47.60%, 208/437) and the 40-44 y age group (44.51%, 154/346). Notably, the positive rate of Chlamydia trachomatis was significantly higher among HPV-positive individuals in comparison to HPV-negatives (16.14% vs. 11.25%, p < .05). Our findings reveal a substantial prevalence of HPV infection among outpatient men in Guangzhou, South China. It is recommended to consider the inclusion of HPV vaccination for adolescent males in national immunization schedules, once an adequate supply of vaccines is accessible.
摘要：
已广泛研究了女性人乳头瘤病毒（HPV）感染的流行病学和临床方面。然而,缺乏有关男性HPV特征的信息.在这项研究中,我们进行了一项回顾性和观察性研究，对2012年至2023年在广州广东省妇女儿童医院门诊就诊的3737名连续男性个体，华南,确定男性HPV的年龄和基因型特异性患病率。结果显示，男性HPV的总体患病率为42.15%(1575/3737)，在不同的诊断人群中，差异从29.55%到81.31%不等。低风险HPV6（15.47%），HPV11（8.94%），高危HPV52(5.51%)是最常见的类型。HPV年患病率显着下降（Z=-3.882，p<.001），从31.44%到52.90%不等。28.77%（1075/3737）的男性表现为单一HPV类型的感染，主要被确定为低风险类型。HPV感染的年龄特异性分布在<25岁年龄组(47.60%,208/437)和40-44岁年龄组(44.51%，154/346)。值得注意的是,与HPV阴性相比，HPV阳性个体中沙眼衣原体的阳性率明显更高（16.14％vs.11.25%,p<.05)。我们的发现揭示了广州门诊男性中HPV感染的大量流行，华南。建议考虑将青少年男性HPV疫苗接种纳入国家免疫计划，一旦获得足够的疫苗供应。
