Abstract：
The ST2/IL-33 signaling pathway has an important role in the host inflammatory response. Here we aimed to study the association of ST2 and IL-33 polymorphisms with serum soluble (s) ST2 and IL-33 concentrations in healthy Finnish children and, in addition, their association with childhood asthma. In total, 146 children were followed from birth to the age 7 years for the development of asthma. Single-nucleotide polymorphisms (SNPs) in ST2 and IL-33 were determined, and associations of the SNP variants with serum levels of sST2 and IL-33 at age of 13 months and with recurrent wheezing and childhood asthma at 7 years of age were analyzed. Children with ST2 rs1041973 AC/AA genotypes had significantly lower level of serum sST2 (2453 pg/mL; IQR 2265) than those with CC genotype (5437 pg/mL; IQR 2575; p = < 0.0001). Similar difference was also observed with ST2 rs13408661. No differences were observed between subjects with studied IL-33 SNPs. Children who carried genetic variants of ST2 rs1041973 or rs13408661 seemed to have a higher risk of asthma. In contrast, children who carried genetic variants of IL-33 rs12551268 were less often diagnosed with asthma. Even though these SNPs seemed to associate with asthma, the differences were not statistically significant.
摘要：
ST2/IL-33信号通路在宿主炎症反应中具有重要作用。在这里，我们旨在研究ST2和IL-33多态性与健康芬兰儿童血清可溶性ST2和IL-33浓度的关联，此外,它们与儿童哮喘的关系。总的来说,从出生到7岁的146名儿童被追踪为哮喘的发展。确定了ST2和IL-33的单核苷酸多态性（SNPs），分析了SNP变异与13月龄时血清sST2和IL-33水平的相关性,以及与7岁时反复喘息和儿童哮喘的相关性.ST2rs1041973AC/AA基因型儿童的血清sST2水平（2453pg/mL；IQR2265）明显低于CC基因型儿童（5437pg/mL；IQR2575；p=<0.0001）。用ST2rs13408661也观察到类似的差异。在具有所研究的IL-33SNP的受试者之间没有观察到差异。携带ST2rs1041973或rs13408661遗传变异的儿童患哮喘的风险更高。相比之下,携带IL-33rs12551268遗传变异体的儿童很少被诊断为哮喘.尽管这些SNP似乎与哮喘有关，差异无统计学意义。
