Abstract：
BACKGROUND: Achondroplasia is a common skeletal dysplasia with a high prevalence of obesity in adulthood. Bariatric surgery has been shown to be effective in treating obesity and related comorbidities, but its feasibility and effectiveness in patients with achondroplasia have not been clearly established.
OBJECTIVE: The objective of this study was to evaluate the feasibility and effectiveness of bariatric surgery in patients with achondroplasia.
METHODS: This study was performed in France, and bariatric surgeons from the Société Française et Francophone de Chirurgie de l\'Obésité et des Maladies Métaboliques (French Francophone Society of Surgery for Obesity or Metabolic Diseases) were asked to participate.
METHODS: Two adult women with confirmed achondroplasia and a high BMI were selected for laparoscopic sleeve gastrectomy. Preoperative data were collected, including demographic information, comorbidities, and follow-up at 1, 3, and 6 months and 1 year after surgery. Complications were monitored and recorded.
RESULTS: Both patients had good excess weight loss outcomes, with an average excess weight loss of 60.5% 1 year after surgery. One patient had a follow-up of 3 years and an excess weight loss of 44%. The surgery was well-tolerated, and no major complications were observed.
CONCLUSIONS: Bariatric surgery is feasible and effective in patients with achondroplasia, with good outcomes for excess weight loss and related comorbidities. These findings suggest that bariatric surgery should be considered a treatment option for patients with achondroplasia and obesity.
OBJECTIVE: The objective of this study was to evaluate the feasibility and effectiveness of bariatric surgery in patients with achondroplasia.
METHODS: This study was performed in France, and bariatric surgeons from the Société Française et Francophone de Chirurgie de l\'Obésité et des Maladies Métaboliques (French Francophone Society of Surgery for Obesity or Metabolic Diseases) were asked to participate.
METHODS: Two adult women with confirmed achondroplasia and a high BMI were selected for laparoscopic sleeve gastrectomy. Preoperative data were collected, including demographic information, comorbidities, and follow-up at 1, 3, and 6 months and 1 year after surgery. Complications were monitored and recorded.
RESULTS: Both patients had good excess weight loss outcomes, with an average excess weight loss of 60.5% 1 year after surgery. One patient had a follow-up of 3 years and an excess weight loss of 44%. The surgery was well-tolerated, and no major complications were observed.
CONCLUSIONS: Bariatric surgery is feasible and effective in patients with achondroplasia, with good outcomes for excess weight loss and related comorbidities. These findings suggest that bariatric surgery should be considered a treatment option for patients with achondroplasia and obesity.
摘要：
背景：软骨发育不良是一种常见的骨骼发育不良，成年期肥胖患病率高。减肥手术已被证明是有效的治疗肥胖和相关的合并症，但其在软骨发育不全患者中的可行性和有效性尚未明确确定。
目的：本研究的目的是评估软骨发育不全患者减重手术的可行性和有效性。
方法：本研究在法国进行，法国法语和法语国家医院的减肥外科医生(法国法语国家肥胖或代谢疾病外科学会)被邀请参加。
方法：选择两名确诊为软骨发育不全且BMI较高的成年女性行腹腔镜袖状胃切除术。收集术前数据,包括人口统计信息，合并症,术后1、3、6个月和1年随访。监测并记录并发症。
结果：两名患者均有良好的超重减轻结果，术后1年平均体重下降60.5%。一名患者的随访时间为3年，体重减轻了44％。手术耐受性良好,未观察到重大并发症。
结论：减重手术治疗软骨发育不全患者是可行和有效的，对过度减肥和相关合并症有良好的效果。这些发现表明，减肥手术应被视为软骨发育不全和肥胖患者的治疗选择。
目的：本研究的目的是评估软骨发育不全患者减重手术的可行性和有效性。
方法：本研究在法国进行，法国法语和法语国家医院的减肥外科医生(法国法语国家肥胖或代谢疾病外科学会)被邀请参加。
方法：选择两名确诊为软骨发育不全且BMI较高的成年女性行腹腔镜袖状胃切除术。收集术前数据,包括人口统计信息，合并症,术后1、3、6个月和1年随访。监测并记录并发症。
结果：两名患者均有良好的超重减轻结果，术后1年平均体重下降60.5%。一名患者的随访时间为3年，体重减轻了44％。手术耐受性良好,未观察到重大并发症。
结论：减重手术治疗软骨发育不全患者是可行和有效的，对过度减肥和相关合并症有良好的效果。这些发现表明，减肥手术应被视为软骨发育不全和肥胖患者的治疗选择。
