METHODS: A retrospective review on all patients diagnosed with or treated for FD of the head and neck at the Helsinki University Hospital during 2005-2020.
RESULTS: In total 74 patients were identified; 54% were male and the mean age 45 years. Overall 95% had monostotic FD. Mandibula and maxilla were the most common anatomic sites. Majority of patients had symptoms, most commonly pain and lesion growth, and 49% had extra-skeletal symptoms. For all, diagnosis was primarily based on imaging findings, biopsies were obtained from 41%. Altogether 54 patients (73%) were managed by observation only, 20 patients (27%) received treatment; ten bisphosphonates, six surgery and four both.
CONCLUSIONS: Although highly variable in its clinical manifestations, head and neck FD lesions are often symptomatic and impose risk for extra-skeletal complications. Treatment is often conservative but should be individually tailored. Future studies are encouraged to better define the disease characteristics and hopefully offer new treatment possibilities.
方法:对2005-2020年在赫尔辛基大学医院诊断或治疗头颈部FD的所有患者进行回顾性回顾。
结果:共确定了74例患者;54%为男性,平均年龄45岁。总体上95%患有单核型FD。下颌骨和上颌骨是最常见的解剖部位。大多数病人都有症状,最常见的疼痛和病变生长,49%有骨骼外症状。对于所有人,诊断主要基于影像学发现,活检来自41%.总共54名患者(73%)仅通过观察进行治疗,20名患者(27%)接受治疗;10名双磷酸盐,六个手术和四个都是。
结论:尽管其临床表现差异很大,头颈部FD病变通常是有症状的,并且存在骨骼外并发症的风险。治疗通常是保守的,但应该单独定制。鼓励未来的研究更好地定义疾病特征,并希望提供新的治疗可能性。