PDF(Pubmed)
Abstract：
OBJECTIVE: This study aims to biomimetic design a new 3D-printed lattice hemipelvis prosthesis and evaluate its clinical efficiency for pelvic reconstruction following tumor resection, focusing on feasibility, osseointegration, and patient outcomes.
METHODS: From May 2020 to October 2021, twelve patients with pelvic tumors underwent tumor resection and subsequently received 3D-printed lattice hemipelvis prostheses for pelvic reconstruction. The prosthesis was strategically incorporated with lattice structures and solid to optimize mechanical performance and osseointegration. The pore size and porosity were analyzed. Patient outcomes were assessed through a combination of clinical and radiological evaluations.
RESULTS: Multiple pore sizes were observed in irregular porous structures, with a wide distribution range (approximately 300-900 μm). The average follow-up of 34.7 months, ranging 26 from to 43 months. One patient with Ewing sarcoma died of pulmonary metastasis 33 months after surgery while others were alive at the last follow-up. Postoperative radiographs showed that the prosthesis\'s position was consistent with the preoperative planning. T-SMART images showed that the host bone was in close and tight contact with the prosthesis with no gaps at the interface. The average MSTS score was 21 at the last follow-up, ranging from 18 to 24. There was no complication requiring revision surgery or removal of the 3D-printed hemipelvis prosthesis, such as infection, screw breakage, and prosthesis loosening.
CONCLUSIONS: The newly designed 3D-printed lattice hemipelvis prosthesis created multiple pore sizes with a wide distribution range and resulted in good osteointegration and favorable limb function.
METHODS: From May 2020 to October 2021, twelve patients with pelvic tumors underwent tumor resection and subsequently received 3D-printed lattice hemipelvis prostheses for pelvic reconstruction. The prosthesis was strategically incorporated with lattice structures and solid to optimize mechanical performance and osseointegration. The pore size and porosity were analyzed. Patient outcomes were assessed through a combination of clinical and radiological evaluations.
RESULTS: Multiple pore sizes were observed in irregular porous structures, with a wide distribution range (approximately 300-900 μm). The average follow-up of 34.7 months, ranging 26 from to 43 months. One patient with Ewing sarcoma died of pulmonary metastasis 33 months after surgery while others were alive at the last follow-up. Postoperative radiographs showed that the prosthesis\'s position was consistent with the preoperative planning. T-SMART images showed that the host bone was in close and tight contact with the prosthesis with no gaps at the interface. The average MSTS score was 21 at the last follow-up, ranging from 18 to 24. There was no complication requiring revision surgery or removal of the 3D-printed hemipelvis prosthesis, such as infection, screw breakage, and prosthesis loosening.
CONCLUSIONS: The newly designed 3D-printed lattice hemipelvis prosthesis created multiple pore sizes with a wide distribution range and resulted in good osteointegration and favorable limb function.
摘要：
目的：本研究旨在仿生设计一种新的3D打印格子半骨盆假体，并评估其在肿瘤切除后骨盆重建中的临床效率。注重可行性,骨整合，和患者结果。
方法：从2020年5月至2021年10月，12例骨盆肿瘤患者接受了肿瘤切除术，随后接受了3D打印的格子半骨盆假体进行骨盆重建。假体战略性地结合了晶格结构和固体，以优化机械性能和骨整合。分析了孔径和孔隙率。通过临床和放射学评估的组合来评估患者结果。
结果：在不规则多孔结构中观察到多种孔径，具有广泛的分布范围（约300-900μm）。平均随访34.7个月,从26到43个月不等。一名尤因肉瘤患者在手术后33个月死于肺转移，而其他人在最后一次随访中还活着。术后X线片显示假体位置与术前计划一致。T-SMART图像显示，宿主骨与假体紧密接触，界面处没有间隙。最后一次随访时MSTS平均得分为21分,从18到24。没有并发症需要翻修手术或移除3D打印的半骨盆假体，如感染，螺钉断裂,和假体松动。
结论：新设计的3D打印点阵式半骨盆假体创造了多种孔径，具有广泛的分布范围，并导致良好的骨整合和良好的肢体功能。
方法：从2020年5月至2021年10月，12例骨盆肿瘤患者接受了肿瘤切除术，随后接受了3D打印的格子半骨盆假体进行骨盆重建。假体战略性地结合了晶格结构和固体，以优化机械性能和骨整合。分析了孔径和孔隙率。通过临床和放射学评估的组合来评估患者结果。
结果：在不规则多孔结构中观察到多种孔径，具有广泛的分布范围（约300-900μm）。平均随访34.7个月,从26到43个月不等。一名尤因肉瘤患者在手术后33个月死于肺转移，而其他人在最后一次随访中还活着。术后X线片显示假体位置与术前计划一致。T-SMART图像显示，宿主骨与假体紧密接触，界面处没有间隙。最后一次随访时MSTS平均得分为21分,从18到24。没有并发症需要翻修手术或移除3D打印的半骨盆假体，如感染，螺钉断裂,和假体松动。
结论：新设计的3D打印点阵式半骨盆假体创造了多种孔径，具有广泛的分布范围，并导致良好的骨整合和良好的肢体功能。
