UNASSIGNED: We reviewed the literature on Ewing\'s Sarcoma of the spine to evaluate its etiology, clinical presentations, differential diagnosis, imaging modalities and management with chemotherapy, radiotherapy, and surgical management. PubMed, EMBASE, Google Scholar and Cochrane key articles were searched. Keywords like \'Ewing\'s Sarcoma,\' \'Spine,\' \'etiology,\' \'treatment,\' \'surgical management,\' and \'en bloc resection\' were used.
UNASSIGNED: The current management of Ewing\'s sarcoma of the spine usually involves three primary modalities: combination chemotherapy, surgery and/or radiotherapy. Recent improvements in combination chemotherapy (vincristine, doxorubicin, cyclophosphamide +/- Ifosfamide and etoposide) are among the most significant factors for improving survival. Also, recent advancements in radiotherapy, instrumentation, and fusion techniques in surgical management have been demonstrated to improve local disease control and overall survival.
UNASSIGNED: Primary Ewing sarcoma of the spine is a rare condition affecting the most common age group of 5-20 years, accounting for 1-3 cases/million/year. About 5 % of cases have spine involvement. Recent improvements in combination chemotherapy have improved the overall survival rates. Enbloc resection and/or radiotherapy have improved local control of the disease.
■我们回顾了有关Ewing\'s脊柱肉瘤的文献,以评估其病因,临床表现,鉴别诊断,影像学模式和化疗管理,放射治疗,和手术管理。PubMed,EMBASE,搜索了GoogleScholar和Cochrane的关键文章。关键词像\'尤因\'s肉瘤,\'\'脊椎,\'\'病因学,\'\'治疗,\'\'手术管理,使用了\'和\'整体切除术\'。
■目前治疗尤因的脊柱肉瘤通常涉及三种主要方式:联合化疗,手术和/或放疗。联合化疗的最新改进(长春新碱,阿霉素,环磷酰胺+/-异环磷酰胺和依托泊苷)是改善生存率的最重要因素之一。此外,放射治疗的最新进展,仪器仪表,和手术治疗中的融合技术已被证明可以改善局部疾病控制和总体生存率。
■脊柱原发性尤因肉瘤是一种罕见疾病,影响最常见的5-20岁年龄组,占1-3例/百万/年。约5%的病例有脊柱受累。最近联合化疗的改进提高了总生存率。整块切除术和/或放射疗法改善了疾病的局部控制。