UNASSIGNED: The research design was an in vivo, three-group, parallel, quadruple-blind study. A total of 75 patients were randomly allocated to one of the three groups-group I: ibuprofen, group II: combination of ibuprofen and paracetamol, and group III: multivitamin (placebo). Premedication was given 45 minutes before treatment, and patients received IANB in a standardized manner. Pain during pulpectomy was recorded using the face, legs, activity, cry, consolability (FLACC) scale and postoperatively using Wong-Baker\'s pain rating scale (WBPRS) at 4, 12, and 24 hours. Success was measured if the pain felt was of no or mild intensity.
UNASSIGNED: Success of IANB was 64% for ibuprofen, 72% for the combination group, and 40% for the placebo group, with no statistically significant difference between all groups (p = 0.06) on the FLACC scale. At 4 hours postoperatively, a significant difference (p = 0.02) was found among groups with more children experiencing no or mild pain in groups I and II and the highest number of rescue medications taken by the placebo group.
UNASSIGNED: Ibuprofen and a combination of ibuprofen and acetaminophen as preemptive analgesics had no significant effect on the success rate of IANB, although it was effective in reducing pain at 4 hours postoperatively.
UNASSIGNED: Gori NA, Patel MC, Bhatt RK, et al. Clinical Assessment of Preemptive Analgesia on Success of Pulpal Anesthesia and Postendodontic Pain in Children with Irreversible Pulpitis: A Randomized Comparative Study. Int J Clin Pediatr Dent 2024;17(1):72-78.
■研究设计是在体内,三组,平行,四重盲研究.共有75名患者被随机分配到三组中的一组-第一组:布洛芬,第二组:布洛芬和扑热息痛的组合,和组III:复合维生素(安慰剂)。在治疗前45分钟给药,患者以标准化方式接受IANB。使用面部记录牙髓切除术期间的疼痛,腿,活动,哭泣,在4、12和24小时使用Wong-Baker疼痛评定量表(WBPRS)进行的可控制性(FLACC)量表和术后。如果感觉到的疼痛是无或轻度的,则测量成功。
■布洛芬的IANB成功率为64%,组合组为72%,安慰剂组为40%,在FLACC量表上,各组之间无统计学差异(p=0.06)。术后4小时,在I组和II组中,出现无痛或轻度疼痛的儿童较多,而安慰剂组的抢救药物数量最多,组间差异显著(p=0.02).
■布洛芬和布洛芬和对乙酰氨基酚的组合作为先发制人的镇痛药对IANB的成功率没有显着影响,尽管它在术后4小时有效减轻疼痛。
■GoriNA,PatelMC,BhattRK,etal.预防性镇痛对不可逆牙髓炎患儿牙髓麻醉成功和牙髓后疼痛的临床评估:一项随机比较研究。IntJClinPediatrDent2024;17(1):72-78。