PDF(Pubmed)
Abstract：
The burden of fungal infections on human health is increasing worldwide. Aspergillus, Candida, and Cryptococcus are the top three human pathogenic fungi that are responsible for over 90% of infection-related deaths. Moreover, effective antifungal therapeutics are lacking, primarily due to host toxicity, pathogen resistance, and immunodeficiency. In recent years, nanomaterials have proved not only to be more efficient antifungal therapeutic agents but also to overcome resistance against fungal medication. This review will examine the limitations of standard antifungal therapy as well as focus on the development of nanomaterials.
摘要：
真菌感染对人类健康的负担在全球范围内日益增加。曲霉菌,念珠菌,隐球菌是人类三大病原真菌，占感染相关死亡的90%以上。此外，缺乏有效的抗真菌疗法，主要是由于宿主毒性，病原体抗性，和免疫缺陷。近年来,纳米材料不仅被证明是更有效的抗真菌治疗药物，而且还可以克服对真菌药物的耐药性。这篇综述将探讨标准抗真菌治疗的局限性以及纳米材料的发展。
