PDF(Pubmed)
Abstract：
During the 1970s, scientists first used botulinum toxin to treat strabismus. While testing on monkeys, they noticed that the toxin could also reduce wrinkles in the glabella area. This led to its widespread use in both medical and cosmetic fields. The objective of the study was to evaluate the potential use of Botox in managing post-operative contracture after below-knee amputation. We conducted a systematic review In Pubmed, Cochrane Library, Embase, and Google Scholar using the MESH terms Botox, botulinum toxin, post-operative contracture, amputation, and below knee amputation. Our goal was to evaluate the potential use of Botox to manage post-operative contracture in patients who have undergone below-knee amputation. Our findings show evidence in the literature that Botox can effectively manage stump hyperhidrosis, phantom pain, and jumping stump, but no clinical trial has been found that discusses the use of Botox for post-operative contracture. Botox has been used in different ways to manage spasticity. Further studies and clinical trials are needed to support the use of Botox to manage this complication.
摘要：
在1970年代,科学家首先使用肉毒杆菌毒素治疗斜视。在猴子身上测试时，他们注意到这种毒素还可以减少glabella区域的皱纹。这导致其在医疗和化妆品领域的广泛使用。该研究的目的是评估Botox在治疗膝下截肢后术后挛缩中的潜在用途。我们在Pubmed中进行了系统评价，科克伦图书馆,Embase,谷歌学者使用MESH术语肉毒杆菌，肉毒杆菌毒素,术后挛缩,截肢,膝盖以下截肢。我们的目标是评估Botox在膝盖以下截肢患者术后挛缩中的潜在用途。我们的研究结果表明，文献中的证据表明，肉毒杆菌毒素可以有效地管理残端多汗症，幻影疼痛,跳跃树桩，但尚未发现临床试验讨论使用肉毒杆菌素治疗术后挛缩。肉毒杆菌毒素已被以不同的方式用于控制痉挛。需要进一步的研究和临床试验来支持使用肉毒杆菌来管理这种并发症。
