Abstract：
Renal cell carcinoma (RCC) is derived from renal tubular epithelial cells and is among the 10 most common cancers worldwide. Incidence of renal cell carcinoma is 400,000 individuals worldwide per year. The age of diagnosis is approximately 60years, and twice as many men are diagnosed as women. African Americans have a slightly higher rate of RCC than do White peoples. The reasons for this are not clear. Inherited syndromes in family, long term dialysis, smoking individuals who had quit smoking >10 years prior had a lower risk when compared to those who had quit <10 years. 22.5 pack-year smokers had a more than 50.0% increased RCC risk compared to nonsmokers, high body mass index i.e. 5kg/m2 increase in body mass index (BMI) was found to be strongly associated with RCC. BMI >35kg/m2 is associated with higher incidence of Cancer raise blood pressure- Higher BMI and hypertension were independently shown to increase the long-term risk of RCC in men. A rise of blood pressure of 10mmHg is associated with 10-22 percent risk of RCC. Clear cell carcinoma is the most common variety of renal cell carcinoma as compared to other varieties of renal cell carcinomas (68.0-75.0%). It has also been found that CAIX is positive for all papillary renal cell carcinoma and negative for CK7, AMACR & TEF. We also found that CK7, EMA, CD117 and CAIX are most commonly positive for all chromophobe renal cell carcinoma. It has been found that clear cell carcinoma is the most common variety of renal cell carcinoma as compared to other varieties of renal cell carcinomas (68.0-75.0%). Again it has also been found that CAIX is positive for all papillary renal cell carcinoma and negative for CK7, AMACR and TEF. Here it has been found that chromophobe carcinoma is most commonly positive for CK7, EMA, CD117 and CAIX. In a patient coming with signs and symptoms of renal cell carcinoma can be confirmed with the help of histoimmunological markers and in that case one can plan for a proper planning of management.
摘要：
肾细胞癌（RCC）源自肾小管上皮细胞，是全球10种最常见的癌症之一。肾细胞癌的发病率为全世界每年400,000人。诊断年龄约为60岁，被诊断为女性的男性是女性的两倍。非洲裔美国人的RCC率略高于白人。原因尚不清楚。家族遗传综合征,长期透析,与戒烟<10年的吸烟者相比,戒烟前>10年的吸烟者的风险较低.与不吸烟者相比，22.5包年吸烟者的RCC风险增加超过50.0％，发现高体重指数，即体重指数（BMI）增加5kg/m2与RCC密切相关。BMI>35kg/m2与癌症升高血压的发生率较高相关-较高的BMI和高血压独立显示增加男性RCC的长期风险。血压升高10mmHg与10-22%的RCC风险相关。与其他种类的肾细胞癌相比，透明细胞癌是最常见的肾细胞癌（68.0-75.0％）。还发现CAIX对所有乳头状肾细胞癌均为阳性，对CK7，AMACR和TEF均为阴性。我们还发现CK7EMA,CD117和CAIX对所有发色细胞肾细胞癌最常见。已发现，与其他种类的肾细胞癌相比，透明细胞癌是最常见的肾细胞癌（68.0-75.0％）。同样,还发现CAIX对所有乳头状肾细胞癌均为阳性,对CK7、AMACR和TEF均为阴性。这里已经发现，嫌色细胞癌最常见的是CK7，EMA，CD117和CAIX。在患有肾细胞癌的体征和症状的患者中，可以在组织免疫学标记的帮助下进行确认，在这种情况下，可以计划适当的管理计划。
