Abstract：
The ocular thin film presents a potential solution for addressing challenges to ocular drug delivery. In this review, we summarise the findings of a comprehensive review analysing 336 formulations from 68 studies. We investigated the physical and mechanical properties of ocular thin films, categorised into natural polymer-based, synthetic polymer-based, and combined polymer films. The results showed that the type of polymers used impacted mucoadhesion force, moisture absorption:moisture loss ratio, pH, swelling index, and elongation percentage. Significant relationships were found between these properties within each subgroup. The results also highlighted the influence of plasticisers on elongation percentage, mucoadhesion force, swelling index, and moisture absorption:moisture loss ratio. These findings have implications for designing and optimising ocular drug formulations and selecting appropriate plasticisers to achieve formulations with the desired properties.
摘要：
眼部薄膜为解决眼部药物递送的挑战提供了潜在的解决方案。在这次审查中,我们总结了对68项研究的336种配方进行全面分析的结果。我们研究了目镜薄膜的物理和机械性能，归类为基于天然聚合物的，合成聚合物基，和组合的聚合物薄膜。结果表明，使用的聚合物类型会影响粘膜粘附力，吸湿：水分损失率，pH值,肿胀指数,和伸长率。在每个子组的这些属性之间发现了显着的关系。结果还突出了增塑剂对伸长率的影响，粘膜粘合力，肿胀指数,和吸湿：水分损失率。这些发现对于设计和优化眼部药物制剂以及选择合适的增塑剂以获得具有所需性质的制剂具有启示。
