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Abstract：
BACKGROUND: Lifestyle plays an important role in preventing and managing gastroesophageal reflux disease (GERD). In response to the conflicting results in previous studies, we performed a systematic review and meta-analysis to investigate this association.
METHODS: Relevant studies published until January 2023 were retrieved from 6 databases, and the prevalence of symptomatic gastroesophageal reflux (GER) or GERD was determined from the original studies. A random effects model was employed to meta-analyze the association by computing the pooled relative risk (RR) with 95% confidence intervals (95%CIs). Furthermore, subgroup and dose-response analyses were performed to explore subgroup differences and the association between cumulative physical activity (PA) time and GERD.
RESULTS: This meta-analysis included 33 studies comprising 242,850 participants. A significant negative association was observed between PA and the prevalence of symptomatic GER (RR = 0.74, 95%CI: 0.66-0.83; p < 0.01) or GERD (RR = 0.80, 95%CI: 0.76-0.84; p < 0.01), suggesting that engaging in PA might confer a protective benefit against GERD. Subgroup analyses consistently indicated the presence of this association across nearly all subgroups, particularly among the older individuals (RR<40 years:RR≥40 years = 0.85:0.69, p < 0.01) and smokers (RRsmoker:RRnon-smoker = 0.67:0.82, p = 0.03). Furthermore, a dose-response analysis revealed that individuals who engaged in 150 min of PA per week had a 72.09% lower risk of developing GERD.
CONCLUSIONS: Maintaining high levels of PA decreased the risk of GERD, particularly among older adults and smokers. Meeting the recommended PA level of 150 min per week may significantly decrease the prevalence of GERD.
METHODS: Relevant studies published until January 2023 were retrieved from 6 databases, and the prevalence of symptomatic gastroesophageal reflux (GER) or GERD was determined from the original studies. A random effects model was employed to meta-analyze the association by computing the pooled relative risk (RR) with 95% confidence intervals (95%CIs). Furthermore, subgroup and dose-response analyses were performed to explore subgroup differences and the association between cumulative physical activity (PA) time and GERD.
RESULTS: This meta-analysis included 33 studies comprising 242,850 participants. A significant negative association was observed between PA and the prevalence of symptomatic GER (RR = 0.74, 95%CI: 0.66-0.83; p < 0.01) or GERD (RR = 0.80, 95%CI: 0.76-0.84; p < 0.01), suggesting that engaging in PA might confer a protective benefit against GERD. Subgroup analyses consistently indicated the presence of this association across nearly all subgroups, particularly among the older individuals (RR<40 years:RR≥40 years = 0.85:0.69, p < 0.01) and smokers (RRsmoker:RRnon-smoker = 0.67:0.82, p = 0.03). Furthermore, a dose-response analysis revealed that individuals who engaged in 150 min of PA per week had a 72.09% lower risk of developing GERD.
CONCLUSIONS: Maintaining high levels of PA decreased the risk of GERD, particularly among older adults and smokers. Meeting the recommended PA level of 150 min per week may significantly decrease the prevalence of GERD.
摘要：
背景：生活方式在预防和管理胃食管反流病（GERD）中起着重要作用。为了回应先前研究中相互矛盾的结果，我们进行了系统评价和荟萃分析来调查这种关联.
方法：从6个数据库中检索到直到2023年1月发表的相关研究，从原始研究中确定了有症状的胃食管反流（GER）或GERD的患病率。采用随机效应模型通过计算95%置信区间(95CIs)的合并相对风险(RR)来荟萃分析相关性。此外，我们进行了亚组和剂量-反应分析,以探讨亚组差异以及累积体力活动时间与GERD之间的关联.
结果：这项荟萃分析包括33项研究，包括242,850名参与者。体力活动与有症状的GER（RR=0.74，95CI：0.66-0.83；p<0.01）或GERD（RR=0.80，95CI：0.76-0.84；p<0.01）的患病率之间存在显着负相关，这表明参加体育锻炼可能会对GERD产生保护性益处。亚组分析一致表明，几乎所有亚组都存在这种关联，尤其是年龄较大的个体(RR<40岁:RR≥40岁=0.85:0.69,p<0.01)和吸烟者(RRsmoker:RRnon-smoker=0.67:0.82,p=0.03)。此外，剂量反应分析显示,每周进行150分钟体力活动的个体发生GERD的风险降低72.09%.
结论：保持高水平的体力活动可降低GERD的风险，尤其是老年人和吸烟者。达到建议的每周150分钟的身体活动水平可能会显着降低GERD的患病率。
方法：从6个数据库中检索到直到2023年1月发表的相关研究，从原始研究中确定了有症状的胃食管反流（GER）或GERD的患病率。采用随机效应模型通过计算95%置信区间(95CIs)的合并相对风险(RR)来荟萃分析相关性。此外，我们进行了亚组和剂量-反应分析,以探讨亚组差异以及累积体力活动时间与GERD之间的关联.
结果：这项荟萃分析包括33项研究，包括242,850名参与者。体力活动与有症状的GER（RR=0.74，95CI：0.66-0.83；p<0.01）或GERD（RR=0.80，95CI：0.76-0.84；p<0.01）的患病率之间存在显着负相关，这表明参加体育锻炼可能会对GERD产生保护性益处。亚组分析一致表明，几乎所有亚组都存在这种关联，尤其是年龄较大的个体(RR<40岁:RR≥40岁=0.85:0.69,p<0.01)和吸烟者(RRsmoker:RRnon-smoker=0.67:0.82,p=0.03)。此外，剂量反应分析显示,每周进行150分钟体力活动的个体发生GERD的风险降低72.09%.
结论：保持高水平的体力活动可降低GERD的风险，尤其是老年人和吸烟者。达到建议的每周150分钟的身体活动水平可能会显着降低GERD的患病率。
