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Abstract：
Introduction Seroma formation is the most common complication after modified radical mastectomy (MRM). It leads to increased pain and discomfort, potentially prolonging morbidity and treatment. Various treatment modalities are being used to decrease the incidence of seroma formation. The objective of this study was to compare intravenous hydrocortisone injection versus placebo in patients undergoing MRM in terms of frequency of post-operative seroma formation. Methods This randomized, double-blinded, placebo-controlled study was conducted at Surgical Unit-I, Holy Family Hospital, Rawalpindi, Pakistan from January 2021 to December 2021. A total of 152 female patients were randomly assigned to each of the study and placebo groups. Group I patients received 100 mg of hydrocortisone intravenously while group II patients received one ml of 0.9% normal saline intravenously prior to induction of general anesthesia for MRM. The incidence of seroma formation after 10 days of MRM and total drain volume till their removal was measured in all patients. Results The mean age was 48.42±10.15 in Group I, while it was 47.67±10.75 in Group II. Mean drain output till removal was 99.14±31.01 ml in the hydrocortisone group and 177.57±63.37 ml in the placebo group. Forty-eight patients developed seroma (31.58%), of whom nine received intravenous hydrocortisone and 39 received normal saline (P=0.000). Conclusion Intravenous hydrocortisone is effective in terms of frequency of post-operative seroma formation as compared to placebo in patients undergoing MRM.
摘要：
简介血清瘤形成是改良根治术（MRM）后最常见的并发症。它导致疼痛和不适增加，可能延长发病率和治疗。正在使用各种治疗方式来降低血清肿形成的发生率。这项研究的目的是比较接受MRM的患者在术后血清肿形成频率方面的静脉氢化可的松注射与安慰剂。方法采用随机、双盲,安慰剂对照研究在手术单元-I进行，神圣的家庭医院，拉瓦尔品第,巴基斯坦从2021年1月到2021年12月。总共152名女性患者被随机分配到每个研究组和安慰剂组。第一组患者静脉注射100mg氢化可的松，而第二组患者在全身麻醉诱导MRM之前静脉注射1ml0.9％生理盐水。在所有患者中测量MRM10天后血清肿形成的发生率和直到清除的总引流量。结果I组平均年龄为48.42±10.15,而第二组为47.67±10.75。氢化可的松组的平均排出量为99.14±31.01ml，安慰剂组为177.57±63.37ml。48例患者出现血清肿(31.58%),其中9人接受静脉注射氢化可的松，39人接受生理盐水（P=0.000）。结论与安慰剂相比，静脉氢化可的松在MRM患者的术后血清肿形成频率方面有效。
