PDF(Pubmed)
Abstract：
UNASSIGNED: Osteoarthritis (OA) commonly occurs following anterior cruciate ligament reconstruction (ACLR), affecting over 50 % of patients within 10-15 years post-ACLR. The Hoffa-synovitis of the infrapatellar fat pad (IPFP) has been implicated as a major contributor to OA pathogenesis. While MRI is typically used to evaluate the IPFP, it is cost-prohibitive for routine screening. This study aimed to validate ultrasound as an alternative for detecting IPFP Hoffa-synovitis in participants post-ACLR.
UNASSIGNED: In this cross-sectional study, 15 participants (18-35 years, 1-5 years post-ACLR) underwent two imaging sessions separated by one week. First, a standardized bilateral anterior knee ultrasound assessment was used to examine IPFP echo-intensity. Second, MRI scans of both knees were graded by a board-certified musculoskeletal radiologist for Hoffa-synovitis according to the Anterior Cruciate Ligament Osteoarthritis Score grading system. IPFP echo-intensity were quantified on each ultrasound image, and a limb symmetry index (LSI) was calculated to assess between-limb differences. We used an independent t-test and Cohen\'s d effect sizes to compare IPFP echo-intensity LSI between people with and without MRI-confirmed Hoffa-synovitis.
UNASSIGNED: Four of the 15 participants (27 %) exhibited MRI-confirmed Hoffa-synovitis. Significantly higher IPFP echo-intensity LSI values were found in participants with Hoffa-synovitis (32.1 ± 12.1 %) compared to those without (10.5 ± 10.4 %), confirming the ultrasound\'s ability to distinguish between the two groups (t = -3.44; p = 0.004; d = 2.01).
UNASSIGNED: Ultrasound detects bilateral IPFP signal intensity alterations in participants post-ACLR with MRI-confirmed Hoffa-synovitis. This work should be seen as a proof-of-concept, and further validation in a larger, more diverse sample is essential for verifying these results.
UNASSIGNED: In this cross-sectional study, 15 participants (18-35 years, 1-5 years post-ACLR) underwent two imaging sessions separated by one week. First, a standardized bilateral anterior knee ultrasound assessment was used to examine IPFP echo-intensity. Second, MRI scans of both knees were graded by a board-certified musculoskeletal radiologist for Hoffa-synovitis according to the Anterior Cruciate Ligament Osteoarthritis Score grading system. IPFP echo-intensity were quantified on each ultrasound image, and a limb symmetry index (LSI) was calculated to assess between-limb differences. We used an independent t-test and Cohen\'s d effect sizes to compare IPFP echo-intensity LSI between people with and without MRI-confirmed Hoffa-synovitis.
UNASSIGNED: Four of the 15 participants (27 %) exhibited MRI-confirmed Hoffa-synovitis. Significantly higher IPFP echo-intensity LSI values were found in participants with Hoffa-synovitis (32.1 ± 12.1 %) compared to those without (10.5 ± 10.4 %), confirming the ultrasound\'s ability to distinguish between the two groups (t = -3.44; p = 0.004; d = 2.01).
UNASSIGNED: Ultrasound detects bilateral IPFP signal intensity alterations in participants post-ACLR with MRI-confirmed Hoffa-synovitis. This work should be seen as a proof-of-concept, and further validation in a larger, more diverse sample is essential for verifying these results.
摘要：
■骨关节炎（OA）通常发生在前交叉韧带重建（ACLR）之后，在ACLR后10-15年内影响超过50%的患者。髌下脂肪垫的Hoffa滑膜炎（IPFP）被认为是OA发病机理的主要原因。虽然MRI通常用于评估IPFP，常规筛查的成本过高.这项研究旨在验证超声作为ACLR后参与者检测IPFPHoffa滑膜炎的替代方法。
■在这项横断面研究中，15名参与者（18-35岁，ACLR后1-5年）进行了两次成像，间隔一周。首先,我们使用标准化的双侧膝前超声评估来检查IPFP回声强度.第二,根据前交叉韧带骨关节炎评分系统，由董事会认证的肌肉骨骼放射科医生对Hoffa滑膜炎的MRI扫描进行分级。在每张超声图像上量化IPFP回波强度，并计算肢体对称指数（LSI）以评估肢体之间的差异。我们使用独立的t检验和Cohen'sd效应大小来比较有和没有MRI证实的Hoffa滑膜炎的人之间的IPFP回声强度LSI。
■15名参与者中有4名（27％）表现出MRI证实的Hoffa滑膜炎。与没有Hoffa滑膜炎的参与者（10.5±10.4％）相比，患有Hoffa滑膜炎的参与者（32.1±12.1％）的IPFP回波强度LSI值明显更高，确认超声对两组的区分能力(t=-3.44;p=0.004;d=2.01)。
■超声检测到参与者在经MRI证实的Hoffa滑膜炎ACLR后的双侧IPFP信号强度改变。这项工作应该被视为一个概念证明，并在更大的范围内进一步验证，更多样化的样本对于验证这些结果至关重要。
■在这项横断面研究中，15名参与者（18-35岁，ACLR后1-5年）进行了两次成像，间隔一周。首先,我们使用标准化的双侧膝前超声评估来检查IPFP回声强度.第二,根据前交叉韧带骨关节炎评分系统，由董事会认证的肌肉骨骼放射科医生对Hoffa滑膜炎的MRI扫描进行分级。在每张超声图像上量化IPFP回波强度，并计算肢体对称指数（LSI）以评估肢体之间的差异。我们使用独立的t检验和Cohen'sd效应大小来比较有和没有MRI证实的Hoffa滑膜炎的人之间的IPFP回声强度LSI。
■15名参与者中有4名（27％）表现出MRI证实的Hoffa滑膜炎。与没有Hoffa滑膜炎的参与者（10.5±10.4％）相比，患有Hoffa滑膜炎的参与者（32.1±12.1％）的IPFP回波强度LSI值明显更高，确认超声对两组的区分能力(t=-3.44;p=0.004;d=2.01)。
■超声检测到参与者在经MRI证实的Hoffa滑膜炎ACLR后的双侧IPFP信号强度改变。这项工作应该被视为一个概念证明，并在更大的范围内进一步验证，更多样化的样本对于验证这些结果至关重要。
