PDF(Pubmed)
Abstract：
Immune nutrition is currently used to enhance fish health by incorporating functional ingredients into aquafeeds. This study aimed to investigate the connections between tryptophan nutrition and the network that regulates the communication pathways between neuroendocrine and immune systems in European seabass (Dicentrarchus labrax). When tryptophan was supplemented in the diet of unstressed fish, it induced changes in the hypothalamic-pituitary-interrenal axis response to stress. Tryptophan-mediated effects were observed in the expression of anti-inflammatory cytokines and glucocorticoid receptors. Tryptophan supplementation decreased pro-opiomelanocortin b-like levels, that are related with adrenocorticotropic hormone and cortisol secretion. When stressed fish fed a tryptophan-supplemented diet were subjected to an inflammatory stimulus, plasma cortisol levels decreased and the expression of genes involved in the neuroendocrine response was altered. Modulatory effects of tryptophan dietary intervention on molecular patterns seem to be mediated by altered patterns in serotonergic activity.
摘要：
免疫营养目前用于通过将功能性成分掺入水产饲料中来增强鱼类健康。这项研究旨在研究欧洲鲈鱼（Dicentrarchuslabrax）中色氨酸营养与调节神经内分泌和免疫系统之间通讯途径的网络之间的联系。当在无压力的鱼的饮食中补充色氨酸时，它引起下丘脑-垂体-肾间轴对应激反应的变化。在抗炎细胞因子和糖皮质激素受体的表达中观察到色氨酸介导的作用。补充色氨酸降低了pro-opiomelanocortinb-like水平，与促肾上腺皮质激素和皮质醇分泌有关。当喂食补充色氨酸的饮食的压力鱼受到炎症刺激时，血浆皮质醇水平下降，参与神经内分泌反应的基因表达改变。色氨酸饮食干预对分子模式的调节作用似乎是由5-羟色胺能活性的改变模式介导的。
